ImmunesensingofCandidaalbicansrequirescooperativerecognitionofmannansandglucansbylectinandToll-likereceptors
...amultilayeredcellwallcomposedofanouterlayerofproteinsglycosylatedwithN-orO-linkedmannosylresiduesandaninnerskeletallayerof?-glucansandchitin.WedemonstratethatcytokineproductionbyhumanmononuclearcellsormurinemacrophageswasmarkedlyreducedwhenstimulatedbyC.albicansmutantsdefectiveinmannosylation.Recogn...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第6期ComparativeAnalysisofImmunoglobulinM(IgM)CaptureEnzyme-LinkedImmunosorbentAssayUsingVirus-LikeParticlesorVirus-InfectedMouseBrainAntigensTo
...evention,PublicHealthService,U.S.DepartmentofHealthandHumanServices,FortCollins,Colorado80522ABSTRACTTheuseofimmunoglobulinM(IgM)antibody-captureenzyme-linkedimmunosorbentassay(MAC-ELISA)servesasavaluabletoolforthediagnosisofacuteflaviviralinfections,sinceIgMantibodytitersaredetectableearly,peakatab...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第7期STAT4在銀屑病患者皮損中的表達及其臨牀意義
...質量,人羣發病率爲0.5%~4.0%,其發病機制可能與遺傳、細胞因子及其受體、新生血管形成、細胞凋亡異常等有關[1~3]。信號轉導和轉錄激活因子(Signaltransducersandactivatorsoftranscription,STAT)蛋白家族是近年來發現的一類轉錄因子...
醫源資料庫;在線期刊;中國熱帶醫學雜誌;2007年第7卷第7期PrivatespecificitiesofCD8Tcellresponsescontrolpatternsofheterologousimmunity
...isvirus;PV,Pichindevirus;VV,vacciniavirus.Variationsinthepathogenesisofviralinfectionscansometimesbeattributedtotheinfectionhistoryofahost,whereexposuretounrelatedpathogensmayunexpectedlycontributeeithertoprotectiveimmunityortoenhancedimmunopathology(1).Thisheterologousimmunityhasnowbeendemonstrated...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第4期StreptococcuspneumoniaeAntigenTestUsingPositiveBloodCultureBottlesasanAlternativeMethodToDiagnosePneumococcalBacteremia
ClinicalMicrobiologyLaboratory,DukeUniversityMedicalCenter,andDepartmentsofPathologyandMedicine,DukeUniversitySchoolofMedicine,Durham,NorthCarolina27710ABSTRACTRecoveryofStreptococcuspneumoniaefrompositivebloodculturebottlesmaybedifficultduetoautolysisofpneumococci.Therefore,weevaluatedtheperformanc...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第5期Physiologicalpathwayofdifferentiationofhematopoieticstemcellpopulationintomuralcells
...lopinadulthoodfromhematopoieticcellpopulations,especiallythoseofthemonocytelineage.Hereweshowthatmuralcells(MCs),anothercomponentofbloodvessels,developphysiologicallyduringembryogenesisfromahematopoieticstemcell(HSC)population,basedontheinvitrocultureofHSCsandhistologicalexaminationofacutemyeloidleu...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第4期CellCycleSignalingbyEndothelin-1RequiresSrcNonreceptorProteinTyrosineKinase
...intyrosinekinasesiswellestablished,butthephenotypicconsequencesofthesesignalinginteractionsarenotcompletelyunderstood.ToinvestigatetheroleofSrcfamilykinasesinmitogenicsignalingbyGprotein-coupledreceptors,weusedgeneticandpharmacologicalinhibitionofSrctostudycellgrowthinresponsetoendothelin-1.Wefoundt...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第6期一種基因可加速成體組織再生修復
...只在發育的胚胎中產生,在成體中喪失活性,由於其與幹細胞的功能以及癌症有關,因而頗受科學家的關注。發表在11月7日《細胞》雜誌上的這項最新研究表明,這種蛋白質可以提高組織的修復能力——即使是在成體中。實驗中...
行業資訊;臨牀快報;遺傳與基因組8-4可控性蛋白降解與信號轉導
...ehog、Notch、NF-κB等信號途徑,這些信號途徑往往影響相鄰細胞的分化,稱爲側向信號發放(lateralsignaling)。 一、Wnt信號途徑 Wnt是一類分泌型糖蛋白,通過自分泌或旁分泌發揮作用。在小鼠中,腫瘤病毒整合在Wnt之後而...
醫源資料庫;醫源圖書館;教材類;細胞生物學IdentificationandCharacterizationofClinicalIsolatesofMembersoftheStaphylococcussciuriGroup
...logy,InstituteofBiology,UniversityofBialystok,Bialystok,PolandDepartmentofClinicalMicrobiology,RegionalHospitalPíbram,PíbramCzechNationalReferenceLaboratoryforStaphylococci,NationalInstituteofPublicHealth,Prague,CzechRepublicDepartmentofBacteriology,PathologyandPoultryDiseases,FacultyofVeterinaryM...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第2期