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IdentificationofaNovelLigandBindingResidueArg38(1.35)intheHumanGonadotropin-ReleasingHormoneReceptor
...ularendoftransmembranedomain1ofthehumanGnRHreceptor.MutationofArg38(1.35)toalanineresultedin989-and1268-foldreductioninaffinityforGnRHIandGnRHII,respectively,thetwoendogenousligands.ConservativemutationofArg38(1.35)tolysinehadlesseffect,givingreducedaffinitiesofGnRHIandGnRHIIby24-and54-fold,respecti...
醫源資料庫；在線期刊；分子藥理學雜誌；2008年第70卷第1期 -
ANovelLossofFunctionMutationofPCSK9GeneinWhiteSubjectsWithLow-PlasmaLow-DensityLipoproteinCholesterol
...rswefoundanovelPCSK9mutationinexon1(c.202delG)resultinginatruncatedpeptide(Ala68fsLeu82X).Twofamilialhypobetalipoproteinemiasubjectsand4hypocholesterolemicblooddonorswerecarriersoftheR46Lsubstitutionpreviouslyreportedtobeassociatedwithreducedlow-densitylipoproteincholesterolaswellasotherrareaminoaci...
醫源資料庫；在線期刊；動脈硬化血栓血管生物學雜誌；2007年第27卷第3期 -
Achievingoptimalessentialfattyacidstatusinvegetarians:currentknowledgeandpracticalimplications
...attyacids.Vegetarian,especiallyvegan,dietsarerelativelylowin-linolenicacid(ALA)comparedwithlinoleicacid(LA)andprovidelittle,ifany,eicosapentaenoicacid(EPA)anddocosahexaenoicacid(DHA).Clinicalstudiessuggestthattissuelevelsoflong-chainn-3fattyacidsaredepressedinvegetarians,particularlyinvegans.n-3Fatt...
醫源資料庫；在線期刊；美國臨牀營養學雜誌；2003年78卷第3期 -
Intakesofessentialn-6andn-3polyunsaturatedfattyacidsamongpregnantCanadianwomen
...maternaldiet.DHAisaccumulatedinthedevelopingbrainandiscriticalfornormalneuralandvisualfunction.Availableestimatessuggestthat67mgDHA/disaccumulatedbythefetusduringthethirdtrimesterofgestation.Littleisknownaboutn-3fattyacidintakesinpregnantwomen,althoughhumanmilkconcentrationsofDHAhavedecreasedinrecen...
醫源資料庫；在線期刊；美國臨牀營養學雜誌；2003年77卷第2期 -
Effectof-linolenicacidsupplementationduringpregnancyonmaternalandneonatalpolyunsaturatedfattyacidstatusandpregnancyoutcome
...nicacid(AA,20:4n-6)maynotbeoptimal.Objective:Ourobjectivewastoimprovematernalandneonatalfattyacidstatusbysupplementingpregnantwomenwithacombinationof-linolenicacid(ALA,18:3n-3)andlinoleicacid(LA,18:2n-6),theultimatedietaryprecursorsofDHAandAA,respectively.Design:Fromweek14ofgestationuntildelivery,pr...
醫源資料庫；在線期刊；美國臨牀營養學雜誌；2004年79卷第2期 -
BindingSiteofaNovelKv1.5Blocker:A“FootintheDoor“againstAtrialFibrillation
【關鍵詞】BindingSiteKv1.5channelblockersprolongatrialactionpotentialsandmaypreventatrialflutterorfibrillationwithoutaffectingventricularrepolarization.Herewecharacterizethemechanismsofactionof2‘-{[2-(4-methoxy-phenyl)-acetylamino]-methyl}-biphenyl-2-carboxylicacid(2-pyridin-3-yl-ethyl)-amide...
醫源資料庫；在線期刊；分子藥理學雜誌；2006年第68卷第10期 -
ActivationoftheCXCR3ChemokineReceptorthroughAnchoringofaSmallMoleculeChelatorLigandbetweenTM-III,-IV,and-VI
...mokineagonists.Molecularmodelingandmolecularsimulationscombinedwithmutationalanalysisindicatedthatthemetalionsite-anchoredchelatorsactasagonistsbyestablishinganaromatic-aromatic,second-siteinteractionwithTyrVI:16ontheinnerfaceofTM-VI.Itisnoteworthythatthisinteractionrequiredthattheextracellularsegme...
醫源資料庫；在線期刊；分子藥理學雜誌；2007年第69卷第3期 -
百日咳毒素S1亞單位的分子修飾及在重組桿狀病毒中的表達
...不同的N-末端存在(表2)，即：天然信號肽(Met-Arg-Cys-Thr-Arh-Ala-Ile-Arg-Gln-Thr)，天然S1亞單位(Asp-Asp-Pro-Pro-Ala-Thr-Val-Tyr-Arg-Tyr)，變異S1亞單位(Asp-Asp-Pro-Pro-Ala-Thr-Val-Tyr-Lys-Tyr)，流感病毒信號肽(Met-Lys-Ala-Lys-Leu-Leu-Val-Leu-Leu-Tyr)。這表明細菌...
合作平臺；醫學論文；臨牀醫學與專科論文；檢驗醫學 -
南開99生物化學
...┴───┴────┘3.某肋的氨基酸組成爲Lys、Val、Arg,Ala、Phe、Tyr和Ser。請根據下列實驗結果，用單字符號表示其排列順序。(a)用FDNB處理，未給出α-DNP__AA，除非預先用chymotVpsin處理，在預處理情況下，從組成分別爲Ala、Tyr...
醫源資料庫；醫源習題集；生物化學 -
絲膠粉對糖尿病的防治作用
...結構爲-Gly-X-Gly-X-，而蠶絲結晶區氨基酸排列的順序爲-Gly-Ala-Gly-Ala-，兩者結構極爲相似。因此，當絲肽的-Gly-a-Gly-Ala-結構進入胰腺後;胰島細胞誤將其當作感受器，從而能誘導胰島素的分泌[16]。 根據以上結論認爲，絲膠在防...
醫源資料庫；在線期刊；中華現代臨牀醫學雜誌；2010年第8卷第10期