Roleofthecaspase-1inflammasomeinSalmonellatyphimuriumpathogenesis
...ports(13,30,31),indicatethatS.typhimuriumpossessesdifferentredundantmechanismstoactivatecaspase-1throughdifferentcomponentsoftheinflammasome.Furthermore,theseresultsindicatethatcontrarytowhathasbeenproposedpreviously,theabsenceofcaspase-1doesnotresultinresistancetoS.typhimuriuminfectionandthatthispa...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第6期Whydoobesepatientsnotlosemoreweightwhentreatedwithlow-caloriediets?Amechanisticperspective
...weightlossobservedinlow-caloriediet(LCD)studiestendstobesmall,andthemechanismsleadingtothislowtreatmentefficacyhavenotbeenclarified.Less-than-expectedweightlosswithLCDscanarisefromanincreaseinfractionalenergyabsorption(FEA),adaptationsinenergyexpenditure,orincompletepatientdietadherence.Wesystematic...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2007年85卷第2期PhenotypicModulationofIntimaandMediaSmoothMuscleCellsinFatalCasesofCoronaryArteryLesion
...denceofthrombosis.1Severalfactorshavebeensuggestedtoparticipateinthemechanismsofplaquerupturesuchasalteredmatrixturnoverandbloodrheology,increasedcoagulation,andrecurrentinfections.2MacrophagesandTlymphocytesareincreasedatsiteofplaquerupture,whereaserosionsandstableplaquescontainrelativelyfewinflamm...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第2期EndovascularTreatmentofCerebralMycoticAneurysms1
...REFERENCES:PURPOSE:Toevaluatetheendovasculartreatment(EVT)ofmycoticaneurysms(MAs).:MATERIALSANDMETHODS:Clinicalandradiologicdataof18MAstreatedwithEVTwereretrospectivelyreviewed.Therewere14patients(11men,threewomen),ranginginagefrom28to64(meanage,44years).Allpatientshadendocarditisandpositivebloo...
醫源資料庫;在線期刊;放射學雜誌;2003年1月第226卷第2期VitaminEInhibitsAbdominalAorticAneurysmFormationinAngiotensinII–InfusedApolipoproteinE–DeficientMice
...42.E-mailneal-weintraub@uiowa.eduAbstractBackground—Abdominalaorticaneurysms(AAAs)inhumansareassociatedwithlocallyincreasedoxidativestressandactivityofNADPHoxidase.WeinvestigatedthehypothesisthatvitaminE,anantioxidantwithdocumentedefficacyinmice,canattenuateAAAformationduringangiotensinII(AngII)in...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第8期Relationbetweendietaryn3andn6fattyacidsandclinicallydiagnoseddryeyesyndromeinwomen
...reconsistentwithanecdotalclinicalobservationsandpostulatedbiologicalmechanisms.KeyWords:Epidemiologydryeyesyndromedietn3fattyacidsn6fattyacidsriskfactorswomenINTRODUCTIONDryeyesyndrome(DES)isoneofthemostprevalentocularconditionsintheUnitedStatesandafre...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2005年82卷第4期DistributionofInsertion-andDeletion-AssociatedGeneticPolymorphismsamongFourMycobacteriumtuberculosisPhospholipaseCGenesandAssociationswithExt
...hefourplcgenestothepathogenesisofhumanTB,weinvestigatedthegeneticpolymorphismsofallfourplcgenesandcomparedthedistributionoftheirgenotypesamongstudysubjectswithdifferentclinicalpresentationsusingacasecontrolstudydesign.MATERIALSANDMETHODSStudysampleandbacterialisolates.Weincluded682culture-confirmedM...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第12期IschemicNeoangiogenesisEnhancedby2-AdrenergicReceptorOverexpression
...ardiacfibroblastscaninducecellproliferationthroughERK/MAPK-dependentmechanisms.8OurcurrentdatademonstratethatthissignalingparadigmalsoexistsinECsbecause2ARstimulationincreasedECnumber,andthiscellularproliferativeeffectisblockedbyERK/MAPKinhibition.Althoughwedidnotinvestigatethewholesignaltransductio...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第11期InVivoandInVitroStudiesSupportThataNewSplicingIsoformofOLR1GeneIsProtectiveAgainstAcuteMyocardialInfarction
...sinmyocardialinfarction(MI)susceptibility.Becausesinglenucleotidepolymorphisms(SNPs)linkedtoMIarelocatedinintronicsequencesofthegene,itremainsunclearastohowtheydeterminetheirbiologicaleffects.Usingquantitativereal-timePCRandminigeneapproach,weshowthatintronicSNPs,linkedtoMI,regulatetheexpressionofan...
醫源資料庫;在線期刊;循環研究雜誌;2005年第95卷第7期MolecularBasisofEpithelialBarrierRegulation
...etakenasevidenceoftheirimportance.Itisthereforeofinteresttodefinethemechanismsofalteredintestinalbarrierandtransportfunctionanddevelopmeanstocorrectdisease-associateddefects.Overthepast10years,someofthemoleculareventsunderlyingphysiologicalepithelialbarrierregulationhavebeendescribed.Remarkably,rece...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第12期