抗HIV化學藥物研發推陳出新
...臨牀試驗已在今年年初開始進行。另外還有AMD070、PRO140、AK602、BMS-378806等4個藥物正在進行臨牀I期試驗。■逆轉錄酶抑制劑研究逐漸深入逆轉錄酶抑制劑通過抑制HIV逆轉錄酶,使HIV不能複製從而抑制HIV感染。它可分爲兩類:核苷...
行業資訊;臨牀快報;HIV/AIDS血液灌流與血液透析聯合治療重度有機磷農藥中毒的療效觀察
...合治療,如病情未緩解可重複治療,Hp+HD方法,採用金寶Ak—10血透機,透析器PAN200,膜面積1.4m2,麗珠HA型樹脂腎,將樹脂腎與透析器血路上串聯,樹脂腎在前,透析器在後,血路採取普通動脈、靜脈直接穿刺,肝素抗凝,首劑5...
資料庫;在線期刊;中華現代內科學雜誌;2005年第2卷第1期ClonalSpreadofPediatricIsolatesofCiprofloxacin-Resistant,emmType6Streptococcuspyogenes
...rriedoutinthepresenceoftheeffluxinhibitorreserpine(10μg/ml).Anarbitrarybreakpointforresistancetociprofloxacinof2μg/mlwasusedforquinoloneresistance(12).Isolateswereanalyzedformutationsinthequinoloneresistance-determiningregionsofparCandgyrA.A614-bpPCRfragmentinternaltogyrAanda520-bpfragmentamplifie...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第5期MolecularInteractionsofCCR5withMajorClassesofSmall-MoleculeAnti-HIVCCR5Antagonists
...CR5homologymodeling.Fiveclinicalcandidates:maraviroc,vicriviroc,aplaviroc,TAK-779,andTAK-220wereusedtoestablishthenatureofthebindingpocketinCCR5.Althoughthefiveantagonistsareverydifferentinstructure,shape,andelectrostaticpotential,theywereabletofitinthesamebindingpocketformedbythetransmembrane(TM)do...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第3期TheMiRP2-Kv3.4PotassiumChannel:MusclingInonAlzheimer‘sDisease
...stounaggregatedA1–40ledtoanincreaseinboththeinactivatingIKAcurrent(peak-endcurrent)andIKV(endcurrent),whereasacuteadministrationhadnoeffect.Increasedcurrentwasalsoobservedusingaprotocolemployinga–50mVprepulse,whichremovesthemajorityoftheIKAcurrentcomponent.ThesedatasuggestedthatAdoesnoti...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第9期Sepsis-inducedsuppressionoflunginnateimmunityismediatedbyIRAK-M
...roleoftheLPS/TLR4axisanditsinhibitor,IL-1receptor–associatedkinase–M(IRAK-M),inmodulatingtheimmunosuppressionofsepsisusingamurinemodelofperitonitis-inducedsepsisfollowedbysecondarychallengebyintratrachealPseudomonasaeruginosa.Septicmicedemonstratedimpairedalveolarmacrophagefunctionandincreasedmo...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第9期TGF--activatedkinase1andTAK1-bindingprotein1cooperatetomediateTGF-1-inducedMKK3-p38MAPKactivationandstimulationoftypeIcollagen
...esentstudy,weinvestigatedthefunctionalroleofupstreamTGF--activatedkinase1(TAK1)andTAK1-bindingprotein1(TAB1)intheTGF-1signalingcascade.RapidactivationofendogenousTAK1activitybyTGF-1wasobservedinmousemesangialcells.TransientoverexpressionofTAK1withTAB1enhancedtheactivationofMKK3andp38MAPKwithorwithou...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第5期AWaterborneOutbreakofNorwalk-LikeVirusamongSnowmobilersWyoming,2001
...specimenand6ofthepositivestoolsampleswereidentical.ThismultistrainNLVoutbreakinvestigationillustratestheimportanceofNLVasacauseofwaterborneillnessandshouldencouragemonitoringforNLVsindrinkingwater. Presentaffiliation:FoodborneandDiarrhealDiseasesBranch,DivisionofBacterialandMycoticDiseases,Centers...
醫源資料庫;在線期刊;傳染病學雜誌;2003年第187卷第2期Waistcircumferenceisassociatedwithpulmonaryfunctioninnormal-weight,overweight,andobesesubjects
...yMedicine,FacultyofMedicine,UniversityofOttawa,451SmythRoad,Ottawa,ON,CanadaK1H8M5.E-mail:ychen{at}uottawa.ca.ABSTRACTBackground:Obesityisbecomingaseriouspublichealthissueandisrelatedtolungdysfunction.Becausebothweightandheightareindicatorsofbodysize,bodymassindex(BMI)maynotbeanidealindexofobesityin...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2007年85卷第1期Canextrauterinegrowthapproximateintrauterinegrowth?Shouldit?
...tproductionisneededtomaintainbodytemperature.Atthesametime,physicalchangestakeplacethathelptolimitheatloss.Theskinofapreterminfantmaturesveryrapidlyandat12wkafterbirthisnotverydifferentfromthatofaterminfantatbirth(11).Thisrapidskinmaturationlimitsheatlossthroughevaporation.Thenewbornhastodefen...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2007年85卷第2期