ModulationofTissueFactor–FactorVIIaSignalingbyLipidRaftsandCaveolae
...onlyinitiatesthecoagulationcascadebutalsoinducescellsignalingbyactivatingG-proteincoupledprotease-activatedreceptors.TheobjectiveofthepresentstudyistoinvestigatetheroleoflipidraftsandcaveolaeinmodulatingTF-VIIasignalingandcoagulantfunctions.MethodsandResults—TF-VIIacoagulantfunctionwasmeasured...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第6期心肌預缺血:一種內源性的心肌保護機制
...ol,DAG)。DAG可使本來處於細胞漿內非激活狀態的蛋白激酶C(proteinKinaseC,PKC)移到細胞的雙層脂膜上,等待後缺血期激活[12]。蛋白激酶C有幾種異構體,預缺血時誘導的是新型的鈣非依賴型酶。該酶在後缺血和再灌注期通過上述腺...
合作平臺;醫學論文;內科學論文;心血管病學Expressionandinteractionoftwocompoundheterozygousdistalrenaltubularacidosismutantsofkidneyanionexchanger1inepithelialcells
【摘要】KidneyAE1(kAE1)isaglycoproteinresponsiblefortheelectroneutralexchangeofchlorideforbicarbonate,promotingthereabsorptionofbicarbonateintothebloodby-intercalatedcellsofthecollectingtubule.MutationsoccurringinthegeneencodingkAE1caninducedefectsinurinaryacidificationresultingindistalrenaltubu...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第12期ChallengesandOpportunitiesofTrappingLigands
...ptorspecies-specific.AlthoughanalogousmodelswerepreviouslyproposedforotherGprotein-coupledreceptors,thestudybyKohoutetal.(2007)providesanimportantadvanceintheGnRHantagonistsfieldandanillustrationofthefactthatpreclinicalstudiesusinganimalmodelswithnonhumanreceptorsmayhaveverylimitedvalueinpredictingd...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第8期Prostatecancerpreventionbynutritionalmeanstoalleviatemetabolicsyndrome
...kegrowthfactor-I(IGF-I),andfreetestosteronewithincreasesinSHBGandIGFbindingprotein-1.HyperinsulinemiastimulatesliverproductionofIGF-I,playsaroleinthepromotionofprostatecancer,andthusisthecornerstoneforbothMSandprostatecancer.Adoptingalow-fatstarchdietwithdailyexercisecontrolsMSandshouldreducetherisk...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2007年86卷第3期Acidosisimpairsinsulinreceptorsubstrate-1-associatedphosphoinositide3-kinasesignalinginmusclecells:consequencesonproteolysis
【摘要】Chronicacidosisisastimulusforproteolysisinmuscleinvivo,butthemechanismofthisresponseisunknown.WetestedthehypothesisthatacidosisorTNF-,acytokinewhoseproductionincreasesinacidosis,regulatesproteolysisbyinhibitinginsulinsignalingthroughphosphoinositide3-kinase(PI3K).InculturedL6myotubes,aci...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第10期Serumproreninlevelsanddiabeticretinopathyintype2diabetes:newmethodtomeasureserumlevelofproreninusingantibodyactivatingdirectkineticassa
....10–12Totalreninwasmeasuredafteractivatinginactiveproreninbytrypsinornon-proteolytically.Atthesametime,activereninwasmeasuredindependently,andthedifferenceinthelevelsbetweentotalreninandactivereninwasdefinedastheproreninlevel.Anewmethodcalledtheantibodyactivatingdirectprorenin(AAD-PR)assay,develop...
醫源資料庫;在線期刊;英國眼科學雜誌;2005年第89卷第7期TheADAMTSProteases,ExtracellularMatrix,andVascularDisease
...lumbiaStreet,Seattle,WA98104-2046.E-mailtwight@hopeheart.orgTheimportanceofproteasesasmediatorsofextracellularmatrix(ECM)degradationandvascularcellphenotypeinthepathogenesisofvasculardiseaseisindisputable.Infact,excellentcasescanbemadeforthematrixmetalloproteinases(MMPs)(seereview1),theserineproteas...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2005年第25卷第1期RosuvastatinTreatmentPreventsProgressiveKidneyInflammationandFibrosisinStroke-ProneRats
...ouslyhypertensivestroke-proneratsshowprogressiveincreasesinbloodpressureandproteinuriaandaccumulateacute-phaseproteinsinbodyfluids,modelingeventsduringrenaldamage.Theaimofthisstudywastoassessthepathologicaleventsoccurringinthekidneyofspontaneouslyhypertensivestroke-proneratsovertimeandevaluatetheeff...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第4期基於本體的語義網絡在中醫藥領域中的應用
...構性、教師本身對概念圖架構的熟悉程度等等。紀軍等用prot6g63.O爲編輯工具,初步構建了鍼灸學的領域本體框架模型,提出在本體的構建過程中主要關注的問題是詞義辨析、同義詞的歸類,上位概念的界定、定義類及其等級體...
合作平臺;醫學論文;中西醫結合論文;中醫中藥