急性髓性白血病細胞自分泌造血生長因子水平及其臨牀意義
...水平測定結果 正常對照組其G-CSF的測定結果爲(53.36±6.58)ng/L,GM-CSF水平均在10ng/L以下,其平均值爲(6.43±2.82)ng/L。21例AML患者其G-CSF測定的平均值爲(76.15±24.11)ng/L;10例(47.6%)AML患者其G-CSF平均值爲(96.44±19.84)ng/L,明顯高於對照組(P>0...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學AnaturallyoccurringhumanNedd4-2variantdisplaysimpairedENaCregulationinXenopuslaevisoocytes
...hENaCPY-motifs.ThesePY-motifsaremutated/deletedinLiddle‘ssyndrome,resultinginelevatedNa+reabsorptionandhypertensionexplainedpartlybyimpairedENaC-Nedd4-2interaction.WehypothesizedthatNedd4-2isasusceptibilitygeneforhypertensionandscreened856renalpatientsandhealthycontrolsformutationsinasubsetofexons...
醫源資料庫;在線期刊;美國生理學雜誌;2004年第287卷第9期依那西普對磨屑誘導骨溶解影響的實驗研究
...:僅爲MΦ;B組:MΦ+鈦顆粒;C組:MΦ+鈦顆粒+依那西普(10ng/ml);D組:MΦ+鈦顆粒+依那西普(100ng/ml);E組:MΦ+鈦顆粒+依那西普(1000ng/ml)。培養18h後,用酶聯免疫法(ELISA)檢測細胞培養上清液中TNF-α、IL-1、IL-6的含量。[結果]B組TN...
醫源資料庫;在線期刊;中國矯形外科雜誌;2008年第16卷第4期StromalCell-DerivedFactor-1InducesMatrixMetalloprotease-13ExpressioninHumanChondrocytes
...etalloproteinase(MMP)-13maycontributetothebreakdownofarticularcartilageduringarthritis.Here,wefoundthatSDF-1increasedthesecretionofMMP-13inculturedhumanchondrocytes,asshownbyreversetranscriptase-polymerasechainreaction,Westernblot,andzymographicanalysis.SDF-1alsoincreasedthesurfaceexpressionofCXCR4r...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第9期RegulationofChemokineExpressionbyNaClOccursIndependentlyofCysticFibrosisTransmembraneConductanceRegulatorinMacrophages
【摘要】Chronicpulmonaryinflammationandinfectionaretheleadingcausesofmorbidityandmortalityincysticfibrosis(CF).Whiletheeffectofmutationofthecysticfibrosistransmembraneconductanceregulator(CFTR)onairwaysremainscontroversial,somegroupshavedemonstratedincreasesinNa+andClCinCFairwaysurfaceliquidcomp...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第7期前列腺穿刺活檢253例的臨牀和病理分析
...2002~2004年間的253例前列腺穿刺標本,根據血清PSA水平(ng/ml)把它們分成7組即:0~4(1),4~10(2),10~20(3),20~30(4),30~40(5),40~50(6),50(7)。對其進行常規的病例診斷和Gleason分級及評分,比較病人的血清PS...
資料庫;在線期刊;中華現代外科學雜誌;2005年第2卷第6期血清TGF-β1和Ⅳ型膠原與糖尿病腎損害
...膠原(ST4C)水平變化及與單純糖尿病(DM組)和正常人(NG組)血清水平差異,探討TGF-β1和ST4C水平變化與DN損害的關係。方法TGF-β1和ST4C:ELISA法;尿白蛋白排泄率(UAER):散射比濁法。結果DN組TGF-β1和ST4C水平明顯高於DM組和NG...
資料庫;在線期刊;中華現代內科學雜誌;2005年第2卷第7期FarnesoidXReceptorLigandsInhibitVascularSmoothMuscleCellInflammationandMigration
...aFXR-SHPpathwaymaybeanoveltherapeutictargetforvascularinflammation,remodeling,andatheroscleroticplaquestability.FXRisexpressedinvascularsmoothmusclecells.Hereweshowthatinadditiontoantiproliferativeproperties,activationofFXRinhibitsinflammationandmigrationofvascularsmoothmusclecells.FXRmaythereforebe...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2007年第27卷第12期SalicylateBlocksLipolyticActionsofTumorNecrosisFactor-inPrimaryRatAdipocytes
...(TNF-),aproinflammatorycytokine,iselevated.TNF-hasavarietyofeffectsbyinducinginflammation,decreasingglucoseutilization,andstimulatingadipocytelipolysistoreleaseFFAtoplasma.Highdosesofnonsteroidalanti-inflammatorydrugsalicylateshavelongbeenrecognizedtolowerbloodFFAandglucoseinhumans,althoughthemechan...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第1期厭食症患者相對於健康體重婦女雄性激素顯著地較低
...康控制組,厭食病患的總睾固酮濃度降低(20.6相較於32.3ng/dl;P0.05),且遊離睾固酮濃度同樣有差異(0.32相較於0.47ng/dl;P0.05);然而,使用口服避孕藥物厭食症病患相較於健康控制組,其DHEA濃度並無差異(155相較於176ng/dl)。...
行業資訊;臨牀快報;內分泌代謝