Regulationofthegerminalcentergeneprogrambyinterferon(IFN)regulatoryfactor8/IFNconsensussequence-bindingprotein
...pment,NationalInstitutesofHealth,Bethesda,MD20892Interferon(IFN)consensussequence-bindingprotein/IFNregulatoryfactor8(IRF8)isatranscriptionfactorthatregulatesthedifferentiationandfunctionofmacrophages,granulocytes,anddendriticcellsthroughactivationorrepressionoftargetgenes.AlthoughIRF8isalsoexpresse...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第1期ProtectiveimmuneresponsesagainstWestNilevirusareprimedbydistinctcomplementactivationpathways
...mentactivationpathwaystotheprotectionfromWNVdisease.GeneticdeficienciesinC1q,C4,factorB,orfactorDallresultedinincreasedmortalityinmice,suggestingthatallactivationpathwaysfunctiontogethertolimitWNVspread.Intheabsenceofalternativepathwaycomplementactivation,WNVdisseminatedintothecentralnervoussystemat...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第5期Removalofhomeostaticcytokinesinksbylymphodepletionenhancestheefficacyofadoptivelytransferredtumor-specificCD8+Tcells
...ls,aswouldbeexpectedbyhomeostaticmechanisms.TheCcytokinesIL-7andIL-15wererequiredforaugmentingTcellfunctionalityandantitumoractivity.RemovalofCcytokine–responsiveendogenouscellsusingantibodyorgeneticmeansresultedintheenhancedantitumorresponsessimilartothoseseenafternonmyeloablativeconditioning.The...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第7期QuantitativeDetectionofHepatitisCVirus(HCV)RNAinSalivaandGingivalCrevicularFluidofHCV-InfectedPatients
...ion.However,theroleoforalfluidsinHCVtransmissionremainscontroversial.HerewequantitativelydeterminedHCVRNAinsalivaandgingivalcrevicularfluid(GCF)ofanti-HCV-positivepatients.Mostpatients(14of18;78%)whosesalivaspecimenswerenegativehadHCVRNAintheirGCF.Mostpatients(20of26;77%)hadhigherHCVRNAlevelsintheir...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第9期ComparisonofemmTypingandRibotypingwithThreeRestrictionEnzymesToCharacterizeClinicalIsolatesofStreptococcuspyogenes
...echaracterizedbyemmtypingandriboprintingusinganautomatedRiboprinter(Dupont/Qualicon)basedonthepatternsproducedbythreerestrictionenzymes,EcoRI,PstI,andHindIII.Threeenzymeswerenecessarytoincreasethediscriminationofribogroupsformedbyeachenzyme.Atotalof40ribogroupsand38emmsequences(notcountingallelicvar...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第1期中華鱉MHCIα2鏈基因克隆及序列分析
...合位點(T-143、K-146、W-147、Y-159)以及β2微球蛋白結合位點(Q-115、A-117、D-119、G-120、D-122),並與人和動物的MHCIaα2存在41.1%~63.9%同源性。結論:Trsi-BX1屬MHCclassIa類基因,可作爲中華鱉種羣的分子標記。MolecularcloningandsequencinganalysisofMH...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學貝那普利和厄貝沙坦對糖尿病大鼠早期血管病變影響
...復染。NF²κB抗體以血管內皮細胞核內出現棕黃色顆粒物質爲陽性,ICAM²1以細胞膜和細胞質黃染爲陽性。計數高倍鏡下同一切片內全部陽性細胞及內皮細胞數,計算NF²κB與ICAM²1的陽性率。應用彩色病理圖文分...
醫源資料庫;在線期刊;齊魯醫學雜誌;2009年第24卷第2期TaqManReal-TimeReverseTranscription-PCRandJDVp26AntigenCaptureEnzyme-LinkedImmunosorbentAssayToQuantifyJembranaDiseaseVirusLoadduringtheAcu
...attleinIndonesia.TheinabilitytopropagatethevirusinvitrohasmadeitdifficulttoquantitateJDVanddeterminethekineticsofvirusreplicationduringtheacutephaseofthediseaseprocess.Wereportforthefirsttimetwotechniquesthatenablequantificationofthevirusandtheuseofthesetechniquestoquantifythevirusloadduringtheacute...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第11期Small-moleculecorrectorsofdefectiveF508-CFTRcellularprocessingidentifiedbyhigh-throughputscreening
...tivecompoundsyieldedseveralclassesofF508-CFTRcorrectors(aminoarylthiazoles,quinazolinylaminopyrimidinones,andbisaminomethylbithiazoles)withmicromolarpotencythatproducedgreaterapicalmembranechloridecurrentthandidlow-temperaturerescue.Correctionwasseenwithin3–6hoursandpersistedformorethan12hoursafte...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第9期ComparisonofHepatitisCVirusNS5band5‘NoncodingGeneSequencingMethodsinaMulticenterStudy
...esensitivitiesrangedfrom64.3to100%andfrom42.7to85.7%forthemethodsthatusedsequencingoftheNS5bregionandthe5‘noncoding(5‘NC)region,respectively.Whenthedatafortheartificiallymixedsampleswereexcluded,NS5bgenotypinggavecorrectresultsfor80%ofthesamples,1.7%ofthesamplesweremisclassified,and18.3%ofthesam...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第2期