揭祕“傳奇青蒿素”:如何從研發到百姓可及
...照一定配比形成的複方蒿甲醚製劑,該組方是全球第一個ACT固定比例複方藥,開創了ACT藥物開發及應用的先河,昆藥成爲全球第一家以青蒿素類藥物爲基礎進行瘧疾治療方法(ACT療法)研究的企業。1998年,複方蒿甲醚以商品名“Coa...
醫藥經濟;生物技術;技術要聞RegulationofHumanHepaticHydroxysteroidSulfotransferaseGeneExpressionbythePeroxisomeProliferator-ActivatedReceptorTranscriptionFactor
...dToxicology,UniversityofAlabamaatBirmingham,Birmingham,Alabama(C.N.F.)AbstractHumanhydroxysteroidsulfotransferaseor(HUMAN)SULT2A1catalyzesthesulfonationofprocarcinogenxenobiotics,hydroxysteroids,andbileacidsandplaysadynamicroleinhepaticcholesterolhomeostasis.Thetreatmentofprimaryculturedhumanhepatoc...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第4期HeatShockProteinsandMitogen-activatedProteinKinasesinSteatoticLiversUndergoingIschemia-Reperfusion:SomeAnswers
...ctofpharmacologicaltreatmentsthatmodulateheatshockproteins(HSPs)andmitogen-activatedproteinkinases(MAPKs).MAPKs,HSPs,proteinkinaseC,andtransaminaselevelsweremeasuredafterreperfusion.WereportthatpreconditioningincreasedHSP72andheme-oxygenase-1(HO-1)at6and24hoursofreperfusion,respectively.Unlikenonste...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第5期HIVandotherpredictorsofserumß-caroteneandretinolinpregnancy:across-sectionalstudyinZimbabwe
...ity,Rolighedsvej30,DK-1958FrederiksbergC,Denmark.E-mail:hfr{at}kvl.dk.ABSTRACTBackground:VitaminAstatusduringpregnancyisimportanttomaternalandinfanthealth.Objective:Ourgoalwastoidentifypredictorsofserumß-caroteneandretinol.Design:Thiswasacross-sectionalstudyof1669women(2235wkofgestation)i...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2001年73卷第6期Long-Actingβ2-AdrenoceptorAgonistsSynergisticallyEnhanceGlucocorticoid-DependentTranscriptioninHumanAirwayEpithelialandSmoothMuscleCells
【關鍵詞】Long-ActingAdditionofaninhaledlong-actingβ2-adrenoceptoragonist(LABA)toaninhaledcorticosteroid(ICS)ismoreeffectiveatimprovingasthmacontrolandreducingexacerbationsthanincreasingthedoseofICS.GiventhatLABAmonotherapyisnotanti-inflammatory,pathwaysmayexistbywhichLABAsenhanceICSaction...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第1期VitaminDfortificationintheUnitedStatesandCanada:currentstatusanddataneeds
...ng8301,MuirkirkRoad,Laurel,MD20910.E-mail:mona.calvo{at}cfsan.fda.gov.ABSTRACTMostcirculating25-hydroxyvitaminDoriginatesfromexposuretosunlight;nevertheless,manyfactorscanimpairthisprocess,necessitatingperiodicrelianceondietarysourcestomaintainadequateserumconcentrations.TheUSandCanadianpopulationsa...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2004年80卷第6期原位肝移植30例麻醉管理的體會
...24例病人術前凝血功能異常,所有轉流病人轉流期間根據ACT值情況應用小量肝素,使ACT值保持在180s左右。凝血異常表現爲APTT、凝血酶原時間(PT)、激活凝血時間(ACT)延長,在手術前比較明顯,無肝前期、無肝期、新肝期得到...
合作平臺;在線期刊;中華醫學研究雜誌;2004年第4卷第7期;臨牀醫學GrowthRegulationviaInsulin-LikeGrowthFactorBindingProtein-and-inAssociationwithMutantK-rasinLungEpithelia
...onarybronchioloalveolarcarcinoma.WeinvestigatedalteredmRNAexpressiononK-Rasactivationinhumanperipherallungepithelialcells(HPL1A)usingoligonucleotidemicroarrays.MutatedK-RasstablyexpressedinHPL1Aacceleratedcellgrowthandinducedtheexpressionofinsulin-likegrowthfactor(IGF)-bindingprotein(IGFBP)-4andIGFB...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第11期假如青蒿素失效消滅耐藥性瘧原蟲成當前瘧疾防控重點
...的搭配藥物用於治療,稱作以青蒿素爲基礎的綜合療法(ACTs)。但在2003年和2004年,首例ACTS耐藥性案例在泰國—柬埔寨邊界出現。起初,研究人員不願意相信青蒿素衍生物正在失效;他們寧願責怪是伴侶藥物失效。2009年,青蒿...
藥品天地;專業藥學;藥學研究Removalofhomeostaticcytokinesinksbylymphodepletionenhancestheefficacyofadoptivelytransferredtumor-specificCD8+Tcells
...stitute,LaJolla,CA92037Depletionofimmuneelementsbeforeadoptivecelltransfer(ACT)candramaticallyimprovetheantitumorefficacyoftransferredCD8+Tcells,butthespecificmechanismsthatcontributetothisenhancedimmunityremainpoorlydefined.EliminationofCD4+CD25+regulatoryT(Treg)cellshasbeenproposedasakeymechanismb...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第7期