DifferentiationofLymphaticEndothelialCellsFromEmbryonicStemCellsonOP9StromalCells
...)andVEGFreceptor-3(VEGFR-3)hasstartedtoprovideanunderstandingofthemolecularmechanismsoflymphangiogenesis.Thehomeoboxgeneprox1hasbeenproventospecifylymphaticendothelialcells(ECs)frombloodECs.WeinvestigatedtheprocessoflymphaticEC(LEC)differentiationusingembryonicstem(ES)cells.MethodsandResults-VEGFR-2...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第9期SynergisticProductionofLungFreeRadicalsbyDieselExhaustParticlesandEndotoxin
...tabolicactivationoforganiccompoundssuchasquinonesinDEPisalsoimplicatedinthemechanismofinvivofreeradicalgeneration(14).AlthoughreactiveoxygenspeciesgeneratedbyDEPeitherdirectlyorindirectlyarebelievedtobeassociatedwiththeadverseeffectsofDEP,noelectronspinresonance(ESR)spin-trappingevidenceofinvivofree...
醫源資料庫;在線期刊;美國呼吸和危急護理醫學;2005年第171卷第2期IdentificationofAminoAcidResiduesintheInsectSodiumChannelCriticalforPyrethroidBinding
...ol,manyarthropodpopulationshavedevelopedresistancetothesecompounds.Onemajormechanismofpyrethroidresistance,knownasknockdownresistance(kdr),wasfirstdiscoveredinhousefliesandsubsequentlyinmanyotherinsectandarachnidspecies(SoderlundandBloomquist,1990).Extensiveresearchinthepastdecadeconvincinglyshowedt...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第2期Milkintakeduringchildhoodandadolescence,adultbonedensity,andosteoporoticfracturesinUSwomen
...),butnotall(2125),epidemiologicstudieshavefoundarelationbetweenlifetimecalciumintakeandadultbonemineraldensity(BMD),fewstudieshaveinvestigatedtheindependenteffectsofcalciumormilkintakeduringchildhoodandadolescence.Dietarybehaviorssuchasmilkandcalciumintakesdevelopedinchildhoodhavebeenshowntope...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2003年77卷第1期EndogenousRGSProteinsandGSubtypesDifferentiallyControlMuscarinicandAdenosine-MediatedChronotropicEffects
...olishedinGi2GS/GScellsbecauseofenhancedsignalingviaapertussistoxinsensitivemechanism.Thus,endogenousRGSproteinspotentlyreducetheactionsofGi/o-linkedreceptorsoncardiacautomaticity.Furthermore,M2andA1receptorsdifferentiallyuseGi2andGoandassociateddownstreameffectors.Thus,alterationsinRGSfunctionmaypla...
醫源資料庫;在線期刊;循環研究雜誌;2006年第96卷第3期FibroblastGrowthFactor-2FailedtoInduceAngiogenesisinJunctionalAdhesionMolecule-A-DeficientMice
...roldifferentfeaturesofvascularhomeostasissuchaspermeabilitytoplasmasolutes,mechanicalstrength,andintegrity.4,14-16Thesemoleculesarealsoinvolvedintransmittingsignalsforendothelialcellsurvival.7,17WehaverecentlyshownthatinquiescentendothelialcellsJAM-Aislocatedatthecell-celljunctions,whereitformsacomp...
醫源資料庫;在線期刊;動脈硬化血栓血管生物學雜誌;2006年第26卷第9期EnergyandfatintakesofchildrenandadolescentsintheUnitedStates:datafromtheNationalHealthandNutritionExaminationSurveys
...ardizedphysicalexaminationofselectedparticipantsinamobileexaminationcenter(MEC).DietaryinterviewswereadministeredtoallexamineesbyatraineddietaryinterviewerfluentinEnglishandSpanishinaprivateroomintheMEC.Respondentsortheirproxiesreportedallfoodsandbeveragesconsumedexceptplaindrinkingwaterfortheprevio...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2000年72卷第5期TheMitochondrialK-ATPChannelOpenerDiazoxidePreventsIschemia-ReperfusionInjuryintheRabbitSpinalCord
...calmanipulationofthisprocess.Forthisreason,ourinteresthascenteredonthebasicmechanismsofinjuryofnervoustissuecausedbyischemiaandreperfusion.Importantmechanismsinischemia-reperfusioninjuryinneuraltissueincludeglutamatereceptor-mediatedexcitotoxicity,generationofreactiveoxygenspecies(ROS),calciuminflux...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第5期Originofatherosclerosisinchildhoodandadolescence
...lefattystreakhaslongbeenanenigma,butnowwehaveaplausiblemolecularandcellularmechanismforitsoriginanditstransformationintoafibrousplaque.ThediscoveryofoxidizedLDL(31)anditsuptakebythemacrophagereceptorforacetylatedLDL(32)ledtotheidentificationofafamilyofmacrophagereceptors,commonlyknownasscavengerrece...
醫源資料庫;在線期刊;美國臨牀營養學雜誌;2000年72卷第5期Podocytesaresensitivetofluidshearstressinvitro
【摘要】Podocytesareexposedtomechanicalforcesarisingfromglomerularcapillarypressureandfiltration.Ithasbeenshownthatstretchaffectspodocytebiologyinvitroandplaysasignificantroleinthedevelopmentofglomerulosclerosisinvivo.However,whetherpodocytesaresensitivetofluidshearstressiscompletelyunknown.Inth...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第10期