Thecharacterizationof5-integrinexpressionontubularepitheliumduringrenalinjury
...oletubularepithelialinjury.Murineprimarytubularepithelialcells(TECs)express5-integrin,afibroblastmarkerandthenaturalreceptorforfibronectin.Microscopylocalized5-integrinonE-cadherin-positivecells,confirmingepithelialexpression.Theexpressionof5-integrinincreasedinTECsgrownonfibronectinandoccurredinpar...
醫源資料庫;在線期刊;美國生理學雜誌;2007年第290卷第2期RegionalDifferencesintheCouplingof5-Hydroxytryptamine-1AReceptorstoGProteinsintheRatBrain
【關鍵詞】5-Hydroxytryptamine-1ANumerousdatashowedthat5-hydroxytryptamine-1A(5-HT1A)receptorscoupletoGo/iproteinsforsignaltransduction.However,thesubunitisoformsreallyinvolvedin5-HT1Areceptorcouplinginbrainremaintobeidentified.Moreover,regionaldifferencesinthefunctionalcharacteristicsofbrain5-H...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第9期小趾囊炎足與正常足X線測量及對比分析研究
...標準。[方法]對131例正常足與117例小趾囊炎足的第4~5蹠骨間角(IM4~5),改良4~5蹠骨間角(MIM4~5),小趾內翻角(MPA),第5蹠骨外翻角(LDA),第5蹠骨頭寬度(WMH)及突出距離(DPMH)進行X線測量,結合臨牀對測量結果進行對比分...
醫源資料庫;在線期刊;中國矯形外科雜誌;2009年第17卷第11期抗人纖維蛋白單鏈抗體的人源化
...維蛋白單鏈抗體的人源化中國免疫學雜誌1999年第12期第15卷學術會議優秀論文選登作者:李文平 許靜 李彬 蔡英林 宋增璇單位:中國協和醫科大學中國醫學科學院血液學研究所實驗血液學國家重點實驗室,天津300020關鍵詞...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學環境檢測(TVOC)檢測方法
...ax-TA管(內含0.1g、0.2g或0.4gTenax-TA);2.2QC-2A大氣採樣儀或TMP1500電子控時採樣器;2.310uL微量注射器;2.4HL800型二次熱解吸儀;2.5GC9800型氣相色譜儀(內含長50m,內徑0.53mm,塗覆二甲基聚硅氧烷的毛細管柱,液膜厚度3.00μm,氫火焰離子...
藥品天地;專業藥學;實驗技術;色譜技術;色譜分析實例AssessmentoftheRolesofSerines5.43(239)and5.46(242)forBindingandPotencyofAgonistLigandsattheHumanSerotonin5-HT2AReceptor
【關鍵詞】5-HT2AWeassessedtherelativeimportanceoftwoserineresidueslocatednearthetopoftransmembranehelix5ofthehuman5-HT2Areceptor,comparingthewildtypewithS5.43(239)AorS5.46(242)Amutations.Usingtheergolinelysergicaciddiethylamide(LSD),andaseriesofsubstitutedtryptamineandphenethylamine5-HT2Arecept...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第11期SubstancePNeurokinin1ReceptorActivationwithintheDorsalRapheNucleusControlsSerotoninReleaseintheMouseFrontalCortex
...depression.Thistherapeuticactivitycouldbemediatedviastimulationofserotonin(5-HT)neuronslocatedinthedorsalraphenucleus(DRN),whichreceiveimportantSP-NK1receptorimmunoreactiveinnervations.ThepresentstudyexaminedtheeffectsofintrarapheinjectionofSPonextracellular5-HTlevelsinthefrontalcortex,ventralhippoc...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第12期RisperidoneIrreversiblyBindstoandInactivatestheh5-HT7SerotoninReceptor
...關鍵詞】RisperidoneRisperidonedisplaysanovelmechanismofantagonismoftheh5-HT7receptor.Pretreatmentofthecellswith5or20nMrisperidone,followedbyremovalofthedrugfromthemedia,rendersthe5-HT7receptorsunresponsiveto10µM5-HTforatleast24h.Thus,risperidoneseemstobeproducingarapid,long-lastinginactiva...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第10期InverseAgonistandNeutralAntagonistActionsofAntidepressantsatRecombinantandNative5-Hydroxytryptamine2CReceptors:DifferentialModulationofCellS
【關鍵詞】InverseDespitetheimportanceof5-hydroxytryptamine(5-HT)2C(serotonin)receptorsinthecontrolofdepressivestates,actionsofantidepressantsatthesereceptorsremainpoorlycharacterized.Thisissuewasaddressedbothinhumanembryonickidney(HEK)-293cellscoexpressinguneditedhuman5-HT2CINIreceptorsandGqpro...
醫源資料庫;在線期刊;分子藥理學雜誌;2008年第70卷第3期TheAminosteroidPhospholipaseCAntagonistU-73122(1-[6-[[17--3-Methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione)PotentlyInhibitsHuma
...ofFrankfurt,Frankfurt,GermanyAbstractU-73122(1-[6-[[17--3-methoxyestra-1,3,5(10)-trien-17-yl]amino]hexyl]-1H-pyrrole-2,5-dione)isawidelyusedantagonistofphosphoinositide-specificphospholipaseC(PLC)andisfrequentlyusedtodefinearoleofPLCinreceptor-mediatedelevationofintracellularcalciumconcentration([Ca...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第5期