第三節 白血病
...用的苯。藥物中的抗癌劑(尤以烷化劑)、乙雙嗎啉、氯黴素、保泰松、安定鎮靜藥、溶劑及殺蟲劑等均可誘發白血病。 三、病毒因素 業已證明,雞、小鼠、貓、牛和長臂猿等動物的自發性白血病與病毒的作用密切相...
醫源資料庫;醫源圖書館;教材類;血液病學C5aandFcreceptors:amutualadmirationsociety
...r,hascross-talkbetweenanothercomplementactivationfragment,theanaphylatoxinC5a,andFcreceptors(FcRs)beendefined.InthisissueoftheJCI,C5aisshowntosignal,viaitsreceptor,theupregulationofactivating(proinflammatory-type)FcRs.Moreover,engagementofFcRsbytheIgG-bearingimmunecomplexinstructsthecelltosynthesize...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第2期小鞏膜瓣下虹膜周邊切除術
...-0尼龍線間斷縫合1針,平鋪結膜,下方球結膜下注射慶大黴素2萬U,地塞米松2.5mg,術畢無菌包紮。2結果術中全部病例虹膜自行脫出,術後全部虹膜周邊切孔通暢,無色素層殘留,大小適中,瞳孔圓、居中,前房形成良好,無一...
合作平臺;在線期刊;中華現代臨牀醫學雜誌;2004年第2卷第5A期RoleofC5inthedevelopmentofairwayinflammation,airwayhyperresponsiveness,andongoingairwayresponse
...entcomponentC5inasthmaremainscontroversial.HereweexaminedthecontributionofC5at3criticalcheckpointsduringthecourseofdisease.UsinganmAbspecificforC5,wewereabletoevaluatethecontributionofC5during(a)theinitiationofairwayinflammation,(b)themaintenanceofairwayhyperresponsiveness(AHR),and(c)sustainmentofan...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第6期TheRoleofComplementinInflammatoryDiseasesFromBehindtheScenesintotheSpotlight
...3aandC3b.C3bcontributestotheformationoftheC5convertase(7),whichcleavesC5toC5aandC5b.C3a,C5a,andtheC5b-9complexarecomplementeffectorsthatcontributetoinflammation(8).Inaddition,theC5b-9complexinduceslysisofgram-negativebacteriaoftheNeisseriagenus.Allthreepathwaysofcomplementactivationleadtotheformatio...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第9期2014年藥物研發最熱門靶點逐個述評
...號通路的藥物包括Pan-PI3K抑制劑、選擇性PI3K抑制劑、雷帕黴素類似物、mTOR活性位點抑制劑、PI3K/mTOR雙靶點抑制劑、Akt抑制劑。已上市的有雷帕黴素類似物temsirolimus、everolimus和選擇性PI3Kδ抑制劑idelalisib。國內自主研發的PI3K抑制...
藥品天地;專業藥學;藥學研究AregulatoryrolefortheC5aanaphylatoxinintype2immunityinasthma
...gpleomorphiceffectsofC5.HerewereportthatlocalpharmacologicaltargetingoftheC5areceptor(C5aR)priortoinitialallergensensitizationinmurinemodelsofinhalationtoleranceorallergicasthmaresultedineitherinductionormarkedenhancementofTh2-polarizedimmuneresponses,airwayinflammation,andAHR.Importantly,C5aR-defic...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第3期Complementactivationinducesdysregulationofangiogenicfactorsandcausesfetalrejectionandgrowthrestriction
...utthemediatorsareundefined.Hereweshowthatcomplementactivation,particularlyC5a,isarequiredintermediaryeventinthepathogenesisofplacentalandfetalinjuryinanantibody-independentmousemodelofspontaneousmiscarriageandIUGR,andthatcomplementactivationcausesdysregulationoftheangiogenicfactorsrequiredfornormalp...
醫源資料庫;在線期刊;實驗醫學雜誌;2006年第203卷第9期Identificationofcellulardeoxyhypusinesynthaseasanoveltargetforantiretroviraltherapy
...ppresseshypusineformationand,thereby,activationofeukaryoticinitiationfactor5A(eIF-5A),acellularcofactoroftheHIV-1Revregulatoryprotein.WedemonstratethatinhibitionofDHSbyCNI-1493orRNAinterferenceefficientlysuppressedtheretroviralreplicationcycleincellcultureandprimarycells.WeshowthatCNI-1493inhibitsre...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第1期氣相色譜在化學工業中的應用
...譜儀就是專門不分析這種混合氧化而設計的。此儀器是用5A分子篩和碳分子篩兩根色譜柱進行分析。在100℃左右柱溫下測定O2、N2、CO、CH4和CO2等氣體組分。5A分子篩可分離O2和N2。 用碳分子篩TDX-01在同樣溫度下分離O2+N2;CO、C...
藥品天地;專業藥學;實驗技術;色譜技術;色譜分析實例