Chemical-BasedTranslationalInductionofLuciferaseExpression:AnEfficientToolforinVivoScreeningofProteinFarnesylationInhibitors
...onate(mevalolactone),andtamoxifenwerefromSigma-Aldrich(St.Louis,MO);ICI182,780wasfromTocrisCooksonInc.(Bristol,UK);PBPEwassynthesizedinourlab(Poirotetal.,2000);andestradiolwasfromSteraloids(London,UK).TransientTransfectionsandTreatments.G418selectedclones(producingR17-eIF-4G-CVLS)weretransientlytran...
醫源資料庫;在線期刊;分子藥理學雜誌;2005年第67卷第6期DelayofPostnatalMaturationSensitizestheMouseProstatetoTestosterone-InducedPronouncedHyperplasia
...on,andtreatmentswithinhibitorsofestrogenaction,aromataseinhibitor,andICI182780furtherexacerbatedtestosterone-inducedhyperplasticgrowth.However,theactivationofestrogenreceptor(ER)-ßwithaspecificagonist,DPN,preventedthedevelopmentofprostatichyperplasiaandinflammationintestosterone-treatedLuRKOmi...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第9期TheAntiestrogenTamoxifenActivatesBKChannelsandStimulatesProliferationofMCF-7BreastCancerCells
...ordedinthepresenceoftheselectiveestrogenreceptorantagonistfaslodex(ICI-182,780;1µM).Atthesingle-channellevel,tamoxifensignificantlyincreasedtheopenprobabilityoftheBKchannelby46.2±10.1%(n=4)withoutchangingitsunitaryconductance.Moreover,weshowherethatthestimulationofBKchannelactivitybytam...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第3期EstrogenReceptorAntagonistFulvestrant(ICI182,780)InhibitstheAnti-InflammatoryEffectofGlucocorticoids
...-inducedpleurisy).Inparticular,wehaveinvestigatedwhetherfulvestrant(ICI182,780),aselectiveER-antagonist,isabletoattenuatethewellknownanti-inflammatoryeffectofdexamethasone(DEX),asyntheticglucocorticoid,inovariectomizedrats.WeshowthatICI182,780,aselectiveER-antagonist,reversestheanti-inflammatoryacti...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第1期NeuroprotectiveEffectsof17-EstradiolandNonfeminizingEstrogensagainstH2O2ToxicityinHumanNeuroblastomaSK-N-SHCells
...againstH2O2insult.Moreover,theestrogenreceptorantagonistfulvestrant(ICI182,780)didnotblockeffectsof17-E2,butincreasedcellsurvivalandbluntedintracellularCa2+increases.However,theseestrogensfailedtoreducecytosolicreactiveoxygenspecies,evenatconcentrationsashighas10µM.Inconclusion,estrogensexertp...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第7期LimitedRedundancyinPhosphorylationofRetinoblastomaTumorSuppressorProteinbyCyclin-DependentKinasesinAcuteLymphoblasticLeukemia
...erredserine612,whichwasinhibitedbyp16INK4a,andfascaplysin.Incontrast,serine780andserine795wereefficientlyphosphorylatedbyCDK4butnotbyCDK2.Thedatasuggestthattheredun-dancyinphosphorylationofRBbyCDK2andCDK4inNalm-6extractsislimited.Serine612phosphorylationbyCDK4alsooccurredinextractsofchildhoodacutely...
醫源資料庫;在線期刊;美國病理學雜誌;2006年第168卷第9期報告稱轉基因作物可促進農業持續、有利且高速發展
...相當於從大氣層中減少了177億kg的二氧化碳,或者相當於780萬量汽車一年的排放量。 減少殺蟲劑的使用(1996-2009)總量爲3.93億kg(-8.7%),從而也降低了除草劑和殺蟲劑對環境的影響,與非轉基因相比,轉基因作物使用量減...
醫藥經濟;生物技術;技術要聞GinsenosideRe,aMainPhytosterolofPanaxginseng,ActivatesCardiacPotassiumChannelsviaaNongenomicPathwayofSexHormones
...igma-Aldrich;SH-6andPP2werepurchasedfromMerck(Darmstadt,Germany),andICI182,780andnilutamidewerepurchasedfromTocris(Ellisville,MO).StocksolutionsofE2(5mM),DHT(5mM),andmifepristone(10mM)werepreparedinethanol;thoseforE-4031(5mM),SMTC(5mM),andL-NIO(1mM)indistilledwater;andthosefornisoldipine(10mM),SH-6(...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第12期慢性非結石性膽囊炎780例超聲診斷
...、高熱、黃疸[1],易誤診。筆者就近一年來超聲檢查780例慢性膽囊炎病例資料總結如下。1資料與方法1.1一般資料本組患者共780例,男465例,女315例,年齡30~75歲。1.2儀器與方法應用PHILIPS彩超診斷儀,探頭頻率12~3MHz。囑受...
醫源資料庫;在線期刊;中華現代影像學雜誌;2008年第5卷第6期780例受血者輸血前傳染性指標檢測的臨牀意義
...指標檢測的臨牀意義。方法採用酶聯免疫吸附(ELISA)法對780例輸血前患者進行乙型肝炎表面抗原(HBsAg)、丙型肝炎病毒抗體(抗-HCV)、艾滋病病毒抗體(抗-HIV)檢測,用梅毒血清學(TRUST)法檢測梅毒抗體。結果780例受血者中HBsAg的陽性...
醫源資料庫;在線期刊;中華現代臨牀醫學雜誌;2009年第7卷第4期