RegulationofHumanConeCyclicNucleotide-GatedChannelsbyEndogenousPhospholipidsandExogenouslyAppliedPhosphatidylinositol3,4,5-trisphosphate
...gsolutionstotheintracellularfaceofthepatch.Inhibitionofcurrentin1mMcGMPby25µML-cis-diltiazem(BIOMOL,PlymouthMeeting,PA)wasusedtoconfirmtheformationofheteromericchannels.Recordingsweremadeat20to22°C.Dose-responserelationshipswereobtainedbyplottingthesteady-statecurrentat+80mVasafunctionofcyclic-nuc...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第1期IsolationandStructure-Activityofμ-ConotoxinTIIIA,APotentInhibitorofTetrodotoxin-SensitiveVoltage-GatedSodiumChannels
【關鍵詞】µ-Conotoxinµ-Conotoxinsarethree-looppeptidesproducedbyconesnailstoinhibitvoltage-gatedsodiumchannelsduringpreycapture.Usingpolymerasechainreactiontechniques,weidentifiedagenesequencefromthevenomductofConustulipaencodinganewµ-conotoxin-TIIIA(TIIIA).A125I-TIIIAbindingassayw...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第3期Agonist-SelectiveMechanismsofμ-OpioidReceptorDesensitizationinHumanEmbryonicKidney293Cells
...2004)ProteinkinaseCactivationenhancesmorphine-inducedrapiddesensitizationofµ-opioidreceptorsinmatureratlocusceruleusneurons.MolPharmacol66:1592-1598.[Abstract/FreeFullText]BohnLM,DykstraLA,LefkowitzRJ,CaronMG,andBarakLS(2004)RelativeopioidefficacyisdeterminedbythecomplementsoftheGprotein-coupledrec...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第8期Interactionoftheμ-OpioidReceptorwithSynaptophysinInfluencesReceptorTraffickingandSignaling
...J,WhiteJH,andMilliganG(2003)SelectiveinteractionsbetweenhelixVIIIofthehumanµ-opioidreceptorsandtheCterminusofperiplakindisruptGproteinactivation.JBiolChem278:33400-33407.[Abstract/FreeFullText]FergusonSS,ZhangJ,BarakLS,andCaronMG(1998)MolecularmechanismsofGprotein-coupledreceptordesensitizationandr...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第1期PhysiologicalDifferencesbetweenHumanandRatPrimaryHepatocytesinResponsetoLiverXReceptorActivationby3-[3-[N-(2-Chloro-3-trifluoromethylbenzyl)-(
...sville,Walkersville,MD)supplementedwithpenicillin(100U/ml),streptomycin(100µg/ml),andgentamicin(100µg/ml),andrathepatocytesweremaintainedinWilliams‘Emedium(Invitrogen,Paisley,Scotland,UK)supplementedwithpenicillin(100U/ml)andstreptomycin(100µg/ml).Insulin(Actrapid;NovoNordiskA/S,Denmark)wasadde...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第10期Short-andLong-TermRegulationofAdenylylCyclaseActivityby-OpioidReceptorAreMediatedbyGi2inNeuroblastomaN2ACells
...4:949-953.[Abstract/FreeFullText]ChakrabartiS,YangW,LawPY,andLohHH(1997)Theµ-opioidreceptordown-regulatesdifferentlyfromthe-opioidreceptor:requirementofahighaffinityreceptor/Gproteincomplexformation.MolPharmacol52:105-113.[Abstract/FreeFullText]CharlesCAandHalesGT(2004)Frominhibitiontoexcitation:Fu...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第6期PhosphorylationofGsInfluencesItsAssociationwiththeμ-OpioidReceptorandIsModulatedbyLong-TermMorphineExposure
...artiS,LawP-Y,andLohHH(1995)Neuroblastomaneuro2Acellsstablyexpressingaclonedµ-opioidreceptor:aspecificcellularmodeltostudyacuteandchroniceffectsofmorphine.MolBrainResearch30:269–278.[Medline]ChakrabartiS,OppermannM,andGintzlerAR(2001)Chronicmorphineinducestheconcomitantphosphorylationandalteredass...
醫源資料庫;在線期刊;分子藥理學雜誌;2007年第69卷第9期富魯達公司生物流體技術可大幅降低研究成本
美國富魯達公司歷經10年研發完成的一種生物流體技術正在生命科學研究領域得到廣泛應用,這種技術可以使生命科學的研究成本大大降低。 富魯達(Fluidigm)是美國一家迅速成長的生物技術儀器公司,目前擁有170項技術專...
醫藥經濟;生物技術;技術要聞楊光富:聚集高端人才推進農藥創新
...資助下,教育部創新團隊帶頭人、華中師範大學教授楊光富率領他的團隊,克難攻堅,先後發展了一系列高效的分子設計策略,成功解決農藥分子的高效性、選擇性和抗藥性三個關鍵科學問題,爲我國綠色農藥研究開創了一條新...
醫學教育;人物專訪挑戰重重“硒”望無限
我國富硒農產品存在概念混淆、標識不清、標準不健全、惡性競爭、魚龍混雜等一系列問題,嚴重影響了硒產業的健康發展。但隨着我國食品功能化和營養化時代的到來,富硒產品將是發展空間巨大的朝陽產業。■本報見習記者...
醫藥經濟;生物技術;技術要聞