-
InVivoResponsivenesstoEzetimibeCorrelateswithNiemann-PickC1Like-1(NPC1L1)BindingAffinity:ComparisonofMultipleSpeciesNPC1L1Orthologs
...rollevelsbyblockingintestinalabsorptionofcholesterol.Ezetimibe(Zetia;Merck/Schering-Plough,Kenilworth,NJ),thefirst-in-classrepresentativeofthe2-azetidinones,blocksbothdietaryandbiliarycholesterolabsorptionintheproximaljejunuminhamsters(Salisburyetal.,1995).Ezetimibeadministrationalsopreventsthedevel...
-
一種新型HCV蛋白酶抑制劑能有效抑制丙型肝
...月期發表的一篇文章,一種新的口服型HCV蛋白酶抑制劑(SCH503034)有很好的耐受性並且可能能夠有效抑制丙型肝炎病毒的1型基因,這種基因在干擾素治療時很難被破壞。研究者表示,SCH503034是NS3蛋白酶的一種特異的抑制劑,而NS...
-
電刺激大鼠腹側被蓋區建立精神分裂症動物模型
...,並給予不同劑量的多巴胺受體拮抗劑氟哌啶醇(HAL)和SCH23390及促多巴胺釋放劑苯丙胺,觀察它們對大鼠精神分裂症模型的影響。結果刺激VTA可引發大鼠的異常行爲,HAL可提高VTA刺激閾值,降低其行爲評分;SCH23390可提高大鼠VTA...
-
左旋多巴誘發異動症大鼠基底節環路功能改變的研究
...節環路功能改變與異動症形成之間的關係。研究者分別以SCH23390(D1受體拮抗劑)、氟哌啶醇(D2受體拮抗劑)治療LID大鼠,觀察LID大鼠的行爲學改變,並用逆轉錄聚合酶鏈反應技術檢測其紋狀體區PDynmRNA和NGFI-BmRNA表達的變化。結果L...
-
小兒過敏性紫癜的心肌損傷
...紫癜過敏性血管炎心肌損傷MyocardialinjuryinchildrenwithHenoch-SchnleinpurpuraSHAOZhu-cheng.TheSecondHospitalofZoucheng,Shandong273500,China.【Abstract】ObjectiveToinvestigatetheincidenceandclinicalcharacteristicsofHenoch-Schnleinpurpura(HSP)withmyocardialinjury.MethodsNinty-th...
-
亞臨牀甲狀腺功能減退與血脂及心腦血管疾病關係的研究
...腦血管疾病亞臨牀甲狀腺功能減退症(SubclinicalHypothyroidism,SCH)是指血清促甲狀腺激素(thyroid-stimulatinghormone,TSH)水平升高,血清遊離甲狀腺素(FreeFhyroxine,FT4)和遊離三碘甲狀腺原氨酸(FreeTriiodothyronine,FT3)水平正常,患者沒有...
-
Agonist-InducedCellSurfaceTraffickingofanIntracellularlySequesteredD1DopamineReceptorHomo-Oligomer
...andtreatmentofvariousneuropsychiatricandneurodegenerativedisordersincludingschizophrenia(LidowandGoldman-Rakic,1994;Okuboetal.,1997),cocaineaddiction(HummelandUnterwald,2002),andParkinson‘sdisease(Emilienetal.,1999).WehavepreviouslyshownthatD1dopaminereceptorsexistashomo-oligomers(Ngetal.,1994;Geo...
-
一平蘇-具有明確血管保護作用的ACEI
...0102030405060SavolainenA,etal.EurHeartJ1994,15:448AmJHypertens2000;13:3s2-3940-4950-5960-6970-1822-3940-4950-5960-6970-1826050403020100年齡,每1000人的校正年齡35-64歲65-94歲脈壓(mmHg)所有組別的P值均0.05Riskofcardiovasculareventsbypulsepressure:30-yearfollow-up,FraminghamStudy根...
-
DopaminerecruitsD1AreceptorstoNa-K-ATPase-richcaveolarplasmamembranesinratrenalproximaltubules
...presentinintracellularcompartmentsunderbasalconditions.Weobserved,using[3H]SCH-23390bindingandimmunoblotting,thatdopaminerecruitsD1Areceptorstotheplasmamembraneinratrenalproximaltubules.Furthermore,radioligandbindingand/orimmunoblottingexperimentsusingpharmacologicalmodulatorsshowedthatdopamine-indu...
-
重視頸椎病發病趨向年輕化
...部運動。附表1頸椎病的發病年齡構成表年齡(歲)20~2930~3940~4950~5960~6970~79合計病歷數110222015169百分比1.4514.4931.8828.9921.741.45100附表2頸椎病各年齡組發病率年齡(歲)20~2930~3940~4950~5960~6970~79調查人數133457726024發病人數11...
-
TheCCR5Receptor-BasedMechanismofActionof873140,aPotentAllostericNoncompetitiveHIVEntryInhibitor
...idinyl)carbonyl]-4‘-methyl-1,4‘-bipiperidin-4-yl}methanoneO-ethyloxime(Sch-C;SCH351125),4,6-dimethyl-5-{[4-methyl-4-((3S)-3-methyl-4-{(1R)-2-(methyloxy)-1-[4-(trifluoromethyl)phenyl]ethyl}-1-piperazinyl)-1-piperidinyl]carbonyl}pyrimidine(Sch-D;SCH417,690),4,4-difluoro-N-((1S)-3-{(3-endo)-3-[3-me...
-
InvolvementofDopamineSysteminRegulationofNa+,K+-ATPaseintheStriatumuponActivationofOpioidReceptorsbyMorphine
...hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepinehydrochloride(SCH23390).However,bothshort-termandlong-termmorphinetreatment-inducedchangesinNa+,K+-ATPaseactivitycouldbereversedbyopioidreceptorantagonistnaltrexone.ItwasfurtherfoundthatcAMP-dependentproteinkinase(PKA)wascruciallyinvolvedi...
-
抗幽門螺桿菌單克隆抗體的製備和臨牀應用
...規鑑定爲Hp菌株,細菌懸液塗片,丙酮固定60min後加Hp-mAbSCH9(1:100稀釋),過夜。洗滌後加辣根過氧化酶標記兔抗鼠IgG(1:250稀釋),室溫1h,洗滌後二氨基聯苯顯色。蒸餾水沖洗終止反應。結果判斷:(-)Hp未染色;(+...
-
大鼠心臟多巴胺1受體與心肌肥厚的關係
...動脈狹窄+倍他樂克組(A+B組);腹主動脈狹窄+倍他樂克+SCH23390組(A+B+S組);假手術+倍他樂克+FODA組(B+F組)。各組均於4周後測定大鼠心功能和左心室/體重比值(LVW/BW);另外還測定了A組心肌肥厚大鼠的心肌組織在FODA作用後cAMP...
-
ReceptorRegulationofGeneExpressionofAxonGuidanceMolecules:ImplicationsforAdaptation
...apseformation,cellmigrationandaxonguidance(Zhou,1998;Klein,2001;KnollandDrescher,2002).Axonguidancemoleculesarealsoexpressedinadultbrainandmaycontributetosynapticfunction,neuroadaptation,andresponsetobraininjury(Gerlai,2001;Hafneretal.,2004;YamaguchiandPasquale,2004;Xiaoetal.,2006).Inthecontextofsyn...
-
PNAS:昆蟲體色的改變有時會致命
...螞蟻,故稱蟻蠶。正常蟻蠶體色爲黑色,一種伴性赤蟻(sch,sex-linkedchocolate)突變,純合型具有巧克力色的體色。由於該基因位於家蠶Z染色體上,所以雜合型只有雌蠶變成了巧克力色,而雄蠶仍然爲黑色。然而,雌蠶“美麗變...
-
TheTwo-StateDimerReceptorModel:AGeneralModelforReceptorDimers
...emicalsInc.,Brea,CA)orfrom0.09to10.5nMoftheD1dopaminereceptorantagonist[3H]SCH23390(85Ci/mmol;PerkinElmerLifeandAnalyticalSciences,Boston,MA)at25°Cin50mMTris-HClbuffer,pH7.4,containing10mMMgClandfor[3H](R)-PIAbinding,0.2U/mladenosinedeaminase(EC3.5.4.4[EC];RocheDiagnosticsS.L.,SantCugatdelVall&e...
-
CD40Ligand
...Medicine,DukeUniversityMedicalCenter,Durham,NC.CorrespondencetoPascalJ.Goldschmidt-Clermont,DivisionofCardiology,DepartmentofMedicine,DukeUniversityMedicalCenter,DUMC3703,Durham,NC27710.E-mailGolds017@mc.duke.eduKeyWords:atherosclerosis•inflammation•CD40ligand•stemcells•endot...
-
西南大學PNAS文章:昆蟲中一種致命的色彩
...螞蟻,故稱蟻蠶。正常蟻蠶體色爲黑色,一種伴性赤蟻(sch,sex-linkedchocolate)突變,純合型具有巧克力色的體色(圖)。由於該基因位於家蠶Z染色體上,所以雜合型只有雌蠶變成了巧克力色,而雄蠶仍然爲黑色。然而,雌蠶“...
-
新的抗血小板治療可降低PCI併發症和出血的危險性
...照的試驗,目的是評價新型口服凝血酶受體拮抗劑(TRA)SCH530348在1,030例NorthAmerica和Europe.患者中的應用。TRA是一個阻斷凝血酶對血小板作用的新型藥物。1,030例患者以3:1的比例被隨機分至10、20或40mg負荷劑量的SCH530348組或安慰劑...
-
破解乙肝丙肝治療之惑——美國肝病研究協會第56屆年會一瞥
...二醇化干擾素無應答患者採用一種口服丙肝蛋白酶抑制劑SCH503034治療。在第一項研究中,研究人員報告了應用SCH503034對原先聚乙烯二醇化干擾素治療無應答的基因1型HCV感染患者的治療結果。患者分別採用SCH503034100毫克每天兩次...
-
Angiotensinmetabolisminrenalproximaltubules,urine,andserumofsheep:evidenceforACE2-dependentprocessingofangiotensinII
...ationofproximaltubules.TheseprocedureswereapprovedbytheWakeForestUniversitySchoolofMedicineIACUCforanimalcare.Proximaltubulepreparation.ProximaltubuleswerepreparedfromamodifiedmethodofVinayetal.(38).Kidneyoutercortexwasmincedintofinepiecesandincubatedwithcollagenase(1mg/ml,CLS1,Worthington)at37°...
-
Voltage-DependentBlockofN-Methyl-D-aspartateReceptorsbyDopamineD1ReceptorLigands
...ngtoNMDAreceptors.Furthermore,usingD1receptorknockoutmice,weverifiedthatthischannel-blockingeffectwasindependentofD1receptors.Finally,wedemonstratedthatD1ligandsfunctionallyinteractwithMg2+blockthroughmultiplesites,implyingapossibleroleofthedirectchannelblockunderphysiologicalconditions.Ourresultssu...
-
RenaldopamineD1receptordysfunctionisacquiredandnotinheritedinobeseZuckerrats
...2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-olhydrochloride([3H]SCH-23390hydrochloride),aD1-receptorantagonist,and35S-labeledguanosine5‘-(-thio)triphosphate([35S]GTPS)werepurchasedfromNewEnglandNuclearLifeSciences.AntibodieswerepurchasedfromAlphaDiagnosticandCalbiochem-Novabiochem.Allot...
-
第二節 組織細胞增生症X
... 組織細胞增生症X(histiocytosisX)包括Letterer-Siwe病,Hand-Schüller-Christian病和骨的嗜酸性肉芽腫(eosinophilicgranuloma)3種疾病。這三種疾病的臨牀表現和病理變化不同。Letterer-Siwe病爲急性瀰漫性,發展快,常表現爲惡性過程;Hand-S...
-
過敏性紫癜的心肌損害
...過敏性;血管炎;心肌損害Myocardialinjuryinchildrenwithhench-SchnleinpurpuraCHENXiong.DepartmentofPediatrics,BeihaiMaternalandChildHealthCareHospital,Beihai536000,China[Abstract]ObjectiveToinvestigatetheincidenceandclinicalcharacteristicsofHench-Schnleinpurpurawithmyocardi...
-
MolecularInteractionsofCCR5withMajorClassesofSmall-MoleculeAnti-HIVCCR5Antagonists
...alpropertieshavealsobeenreportedbyotherpharmaceuticalcompanies.TheseincludeSCH-C(SCH-351125),vicriviroc(VVC,SCH-D,SCH-417690),aplaviroc(APL,AK602,GW873140),andmaraviroc(MVC,UK-427,857).SCH-Cisanoximino-piperidino-piperidineamide(Palanietal.,2002)thatshowedpotentantiviralactivityinvivo.However,itscli...
-
DetectionandQuantificationofHumanImmunodeficiencyVirusType1p24AntigeninDriedWholeBloodandPlasmaonFilterPaperStoredunderVariousCondition
...ctionintoEDTA-containingVacutainertubeswerespottedontofilterpaper(903Paper;SchleicherSchuell,Inc.,Keene,NH).Afterdrying,thespecimenswereplacedincommonplasticZiplocbags.Aliquotsofeachspecimenwerestoredat–80°C,andtotesttheeffectsofvariousambienttemperaturesthatcouldoccurduringspecimentransport,at37...
-
過敏性紫癜患兒抗血管內皮細胞抗體檢測的意義
...ignificanceofanti-endothelialcellsantibodies(AECA)inpatientswithhenoch-schonleinpurpuraTANGXue-qing,SUNWen-ping,ZOUZi-ying.etal.DepartmentofPediatrics,ChengduPLACentralHospital,Chengdu610083,China[Abstract]ObjectiveTostudytherolesofanti-endothelialcellsantibodies(AECA)inthepathogenesisan...
-
OxidativeStressPromotesEndothelialCellApoptosisandLossofMicrovesselsintheSpontaneouslyHypertensiveRats
...ing,UniversityofCalifornia,SanDiego,LaJolla,Calif.CorrespondencetoDrGeertW.Schmid-Sch?nbein,DepartmentofBioengineering,WhitakerInstituteofBiomedicalEngineering,UniversityofCalifornia,SanDiego,9500GilmanDrive,LaJolla,CA92093-0412.E-mailgwss@bioeng.ucsd.eduAbstractObjective—Endothelialcellapoptosisc...