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超級肥胖患者接受十二指腸轉位術減肥效果好
...同事在超級肥胖患者中直接比較了應用十二指腸轉位術(DS)和Roux-en-Y胃旁路術(RYGB)進行膽胰轉道後的體重減輕結果。這是首次針對以上結果進行的大規模單機構研究。科研人員從前瞻性數據庫中確定2002年8月至2005年10月間所...
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唐氏綜合徵產前篩查、診斷預防體系的研究
...綜合徵產前篩查產前診斷 唐氏綜合徵(Down‘ssyndrome,DS)又叫先天愚型,是人類最常見的染色體異常引起的疾病,我國從20世紀90年代後期引進西方先進國家常規開展的孕婦血清篩查DS技術,至今不斷完善的產前篩查及產前診...
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生物檢定統計法(二)
...──┼─────┼────── 第一次實驗 │ds[1] │ds[2] │dT[1] │dT[2] 第二次實驗 │dT[2] │dT[1] │ds[2] │ds[1] ───────┴─────┴─────┴─────┴────── 2.平行...
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生物檢定統計法(三)
...素效價測定──杯碟法 S爲新黴素標準品 稀釋液ds[1]∶0.8u/ml ds[2]∶10.0u/ml ds[3]∶12.5u/ml T爲新黴素 標示量 AT∶670u/mg 稀釋液dT[1]∶8.0u/ml dT[2]∶10.0u/ml dT[3]∶12.5u/ml r=1∶0.8 I=0.0969 ...
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ExogenousNADPHIncreasesCerebralBloodFlowThroughNADPHOxidase–Dependentand–IndependentMechanisms
...effecthavenotbeenfullyelucidated.WeusedapeptideinhibitorofNADPHoxidase(gp91ds-tat)andnullmicelackingthegp91phoxsubunitofNADPHoxidasetoexaminethemechanismsofthecerebrovasculareffectsofexogenousNADPH.MethodsandResults—Cerebralbloodflow(CBF)wasassessedbylaser-Dopplerflowmetryinanesthetizedmiceequippe...
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系統性自身免疫病患者抗核抗體的分類測定
...女13例,男女之比爲1.69∶1。 1.2試劑與檢測項目抗ds-DNA及ENA多肽抗體試劑由美國clark實驗室提供;ds-DNA爲抗IgG和IgM混合物;ENA爲抗IgG、IgA和IgM混合物;ENA抗體爲抗Sm、抗μ1-RNP、抗SS-A、抗SS-B、抗Scl-70和抗Jo-16項。 1.3同...
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ProtectiveEffectoftheHLA-Bw4I80EpitopeandtheKillerCellImmunoglobulin-LikeReceptor3DS1GeneagainsttheDevelopmentofHepatocellularCarcinomain
...suchvirusesasHCV.WefoundthatthehumanleukocyteantigenBw4I80epitopeandtheKIR3DS1geneweremorefrequentinHCVcarriersthaninpatientswithhepatocellularcarcinoma.Moreover,theseassociationswerenotindependentofeachothertheKIR3DS1/Bw4I80genotypeclearlywasalsomorefrequentinHCVcarriers(oddsratio,24.22).NKcellspro...
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AngiotensinIIAttenuatesEndothelium-DependentResponsesintheCerebralMicrocirculationThroughNox-2-DerivedRadicals
...ationthroughROSgeneratedincerebrovascularcellsbytheenzymeNADPHoxidase.MethodsandResults-Cerebralbloodflow(CBF)wasmonitoredbylaserDopplerflowmetryinanesthetizedmiceequippedwithacranialwindow.AngII(0.25±0.02µg/kgperminutefor30to45minutes)attenuatedtheCBFincreaseproducedbytheendothelium-de...
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Homocysteine,Bvitaminstatus,andcognitivefunctionintheelderly
...lth,UniversityofAberdeen,RoyalCornhillHospital,Aberdeen,UnitedKingdom(LJWandSL);andtheDepartmentofPsychology,UniversityofEdinburgh(IJD).2SupportedbytheUnitedKingdomBiotechnologyandBiologicalSciencesResearchCouncil,theScottishExecutiveEnvironmentandRuralAffairsDepartment,andtheWorldCancerResearchFund...
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系統性紅斑狼瘡患者血清膽紅素檢測的臨牀意義
...試驗(ELISA)法測定抗核抗體(ANA);金標法測定雙鏈DNA(ds-DNA)抗體和免疫印跡法檢測多肽抗體(ENA)譜,上述指標用於判定SLE活動期和非活動期。 1.3統計學方法所有數據以x±s表示,組間比較採用配對t檢驗。 2結果 ...
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雙眼單視功能檢查和驗光配鏡
...視角的距離4典型病例例1,患者,女,7歲。原鏡:右4.3-1.0DS=4.7,左4.0-4.0DS=5.0。屈光參差3.0D,四孔燈試驗無一級功能。調整後:右4.3-1.75DS=5.0,左4.0-3.75DS=5.0。屈光參差2.0D,四孔燈試驗二級功能(5m)。點評:此例原鏡的驗光師不知...
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雙眼單視功能檢查和驗光配鏡
...視角的距離4典型病例例1,患者,女,7歲。原鏡:右4.3-1.0DS=4.7,左4.0-4.0DS=5.0。屈光參差3.0D,四孔燈試驗無一級功能。調整後:右4.3-1.75DS=5.0,左4.0-3.75DS=5.0。屈光參差2.0D,四孔燈試驗二級功能(5m)。點評:此例原鏡的驗光師不知...
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NAD(P)HOxidaseInhibitionAttenuatesNeuronalChronotropicActionsofAngiotensinII
...theAT1receptorantagonistlosartanorbytheselectiveNAD(P)Hoxidaseinhibitorgp91ds-tat.ExtracellularapplicationoftheROSscavenger,Tempol,attenuatedtheAngIIeCinducedincreaseinneuronalfiringrateby70%.Inaddition,gp91ds-tattreatmentresultedina50%inhibitionofAngIIeCinducedincreaseinfiringrate.Incontrast,theROS...
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Naturalselectiondrivesrecurrentformationofactivatingkillercellimmunoglobulin-likereceptorandLy49frominhibitoryhomologues
...ctivatingKIR‘sassociationwithresistancetoinfection,reproductivesuccess,andsusceptibilitytoautoimmunity.Ouranalysissuggestsatwo-stagemodelinwhichactivatingKIRorLy49areinitiallysubjecttopositiveselectionthatrapidlyincreasestheirfrequency,followedbynegativeselectionthatdecreasestheirfrequencyandleads...
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HLA-CandKillerCellImmunoglobulin-likeReceptorGenesinIdiopathicBronchiectasis
...HLA-C/KIRcombinationsbygenotypingpatientswithidiopathicbronchiectasis.Methods:GenomicDNAfrom96individualswithidiopathicbronchiectasisand101controlsubjectswasanalyzedbypolymerasechainreactionwithsequence-specificprimers.High-resolutionHLA-CgenotypingwasperformedinadditiontoKIRanalysis.Results:HLA-Cw0...
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糖尿病導致晶體高指數性屈光不正1例
...以上。1年前開始出現雙眼視力下降,在外院驗光後配-6.00DS眼鏡後能清楚視物。6個月前,戴鏡視力又復下降,配-12.00DS眼鏡後視力稍有提高,戴鏡時無明顯不適。全身查體無明顯異常。血糖13.6mmol/L。眼科檢查,雙眼裸眼視力:眼...
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糖尿病導致晶體高指數性屈光不正1例
...以上。1年前開始出現雙眼視力下降,在外院驗光後配-6.00DS眼鏡後能清楚視物。6個月前,戴鏡視力又復下降,配-12.00DS眼鏡後視力稍有提高,戴鏡時無明顯不適。全身查體無明顯異常。血糖13.6mmol/L。眼科檢查,雙眼裸眼視力:眼...
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五種自身抗體在狼瘡性腎炎患者診斷的意義
...體(ANA)、抗可提取性抗原多肽抗體譜(ENA)、抗雙鏈DNA抗體(dsDNA)、抗中性粒細胞胞漿抗體(ANCA)和抗心磷脂抗體(ACA)在狼瘡性腎炎診斷及治療中的意義。方法採用免疫熒光法測定ANA,蛋白芯片法測定ENA多肽抗體譜,金標法測定抗ds-DNA...
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Diet-inducedchangeinfattyacidcompositionofplasmatriacylglycerolsisnotassociatedwithchangeinglucagon-likepeptide1orinsulinsensitivityinpe
AudreyEBrynes,CMarkEdwards,ArvindJadhav,MohammedAGhatei,StephenRBloomandGarySFrost1FromtheNutritionandDieteticResearchGroup,theEndocrineUnit,andtheLipoproteinTeam,ImperialCollegeSchoolofMedicine,HammersmithHospital,London.2SupportedbyaSmallProjectGrantfromtheBritishDiabetesAssociationandadditionalfu...
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MultilocusSequenceTypingofStreptococcusuberisProvidesSensitiveandEpidemiologicallyRelevantSubtypeInformationandRevealsPositiveSelectioninthe
DepartmentofFoodScienceQualityMilkProductionServices,CornellUniversity,Ithaca,NewYork14853ABSTRACTControlofthebovinemastitispathogenStreptococcusuberisrequiressensitiveandepidemiologicallymeaningfulsubtypingmethodsthatcanprovideinsightintothispathogen‘sepidemiologyandevolution.Developmentofamultil...
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FattyAcidsCauseAlterationsofHumanArterialSmoothMuscleCellProteoglycansThatIncreasetheAffinityforLow-DensityLipoprotein
...ve-Thedyslipidemiaofinsulinresistance,withhighlevelsofalbumin-boundfattyacids,isastrongcardiovasculardiseaserisk.Humanarterialsmoothmusclecell(hASMC)matrixproteoglycans(PGs)contributetotheretentionofapoBlipoproteinsintheintima,apossiblekeystepinatherogenesis.WeinvestigatedtheeffectsofhighNEFAlevelso...
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青蒿揮發性化學成分分析
...國FinniganMAT4610B氣相色譜-質譜-計算機聯用儀(GC-MS-DS),同時蒸餾-萃取(SDE)裝置(圖1),Oldshow精餾柱,WMZK-01型恆溫控制儀,重蒸乙醚,無水硫酸鈉(分析純),青蒿全株(夏季採收於江蘇南部丘陵)。1.2同時蒸餾-...
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Diabetesmellitusandserumcarotenoids:findingsofapopulation-basedstudyinQueensland,Australia
...q.edu.au.ABSTRACTBackground:Epidemiologicevidencesuggeststhatserumcarotenoidsarepotentantioxidantsandmayplayaprotectiveroleinthedevelopmentofchronicdiseasesincludingcancers,cardiovasculardisease,andinflammatorydiseases.Theroleoftheseantioxidantsinthepathogenesisofdiabetesmellitusremainsunclear.Objec...
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新一代藥物塗層支架(EXCEL)帶給我們的是什麼?
...所試驗結果QCA結果EXCEL支架(n=32)C型支架(n=28)手術前DS(%)81.1±6.782.6±8.2手術後DS(%)7.11±8.36.2±7.6獲得的管腔直徑(mm)2.51±0.682.35±0.566個月隨訪EXCEL支架(n=12/25)C型支架(n=5/11)DS(%)5.98±5.525.21±6.3晚期管腔丟失(m...
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可降解藥物洗脫支架能帶給我們什麼?
...架(n=31)C型支架(n=30)手術前MLD(mm)0.80±0.151.12±0.41DS(%)73.0±16.065.1±12.6手術後MLD(mm)2.92±0.412.82±0.37DS(%)8.5±4.65.4±8.26個月隨訪Excel支架(n=20/30)C型支架(n=12/18)MLD(mm)2.85±0.372.77±0.46DS(%)11.0±4.710.4±16.5晚期...
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產前篩查在臨牀上的應用
...鍵詞】產前篩查;唐氏綜合徵;神經管缺陷 唐氏綜合徵(DS)也稱先天愚型,是母親生殖細胞形成過程中第21號常染色體由兩條變成三條所致,故又稱21三體綜合徵。DS是一種嚴重的先天性智力障礙性疾病,目前無有效的治療方法,...
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Transportmechanismsforlong-chainpolyunsaturatedfattyacidsinthehumanplacenta
...leforthepreferentialaccumulationofmaternallong-chainpolyunsaturatedfattyacids(LCPUFAs)inthefetus,weinvestigatedfattyaciduptakeandmetabolisminthehumanplacenta.ApreferenceforLCPUFAsovernonessentialfattyacidshasbeenobservedinisolatedhumanplacentalmembranesaswellasinBeWocells,ahumanplacentalchoriocarcin...
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雙側顏面血管瘤及青光眼的Sturge-Weber綜合徵一例
...上、下脣增厚呈深紫色。眼部檢查:右眼視力0.1(-3.00dS-1.00DC×90°=0.5),左眼視力0.08(-3.50dS-2.00DC×90°=0.3)。雙眼球結膜及淺層鞏膜可見數條高度擴張、紆曲的血管。雙眼前節除瞳孔直徑5.5mm、對光反射遲鈍外,餘未見明顯...
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冠心病與免疫
...細胞浸潤8hs間質水腫,中性細胞浸入RBC浸入小血管壞死3ds間質水腫,WBC浸入,RBC浸入4d巨噬細胞清除壞死物,淋巴細胞浸入,成纖維細胞浸入10d中性粒細胞,肉芽組織出現,血管生長,成纖維細胞,清除壞死物4w壞死物清除完畢6w...
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綜合療法治療調節性內斜視伴有弱視的臨牀分析
...ofaccommodativeesotropiawithamplyopiaandtheeffectofcomplextherapytoit.Methods138casesofaccommodativeesotropiawithamplyopiaweretreatedwithcomplexmethods.Theeffectofthistreatmentwasanalyzed.ResultsThe138casesofesotropiaturnedtoemmetropiawithbinocularsinglevision.Theeffectiveratewas94.74%.ConclusionThe...