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鵝去氧膽酸致尿蛋白陽性1例報告
...5~7mm,在腎病好轉,尿蛋白轉陰1個月後取鵝去氧膽酸(CDCA)7.8mg/(kg·d),分3次口服,5天時尿蛋白弱陽性,2天后尿蛋白呈陽性,停服CDCA1周尿蛋白轉陰。2周後改服熊去氧膽酸(UDCA),其是CDˉCA的差向異構體,在3α,7β位有羥...
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口服溶石法療效如何?
...僅有10%左右的病人能治完全療程。 (2)此法費用甚高。CDCA和UDCA售價昂貴,即使國產UDCA50mg片劑,每片也要0.5元。長期連續服用,其費用是很可觀的。 (3)複發率高。一旦停用溶石藥,膽汁3周內便呈過飽和狀態,而膽固醇過...
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第三節 肝與膽汁酸代謝
...類膽汁中存在的膽汁酸主要有膽酸(CA)、鵝脫氧膽酸(CDCA)、脫氧膽酸(DCA),還有少量石膽酸(LCA)及微量熊脫氧膽酸(UDCA)。前4種膽酸在膽汁中的比例通常爲10:10:5:1。 膽汁酸按其在體內來源的不同可分爲初級膽...
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哪些膽囊結石的病人多采用口服溶石療法?
...法。經過不懈的努力,終於在70年代初發現了鵝去氧膽酸(CDCA)具有能溶解結石的作用,從而爲治療膽囊結石開闢了新途徑,也給不願開刀的人帶來一些希望。但目前臨牀上所使用的溶石藥物,不是對每一個膽囊結石病人都適用的...
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膽石症治療方法研究概況如何?
...石 此法又稱膽酸療法,所用藥物主要爲鵝去氧膽酸(CDCA)與熊去氧膽酸(UDCA)兩種。適用於無重度黃疸、發熱、腹痛,無妊娠或合併重症肝、腎、胰疾患,無消化性潰瘍、腸炎的患者。該法主要用於膽固醇結石,且以層狀浮動性...
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膽石症的治療現狀
...。 2 溶石療法 2.1 口服用藥 (1)鵝脫氧膽酸(CDCA)。1971年Thistale等報道CDCA能降低膽汁中膽固醇的飽和度。此後,開展了對此藥的廣泛研究。其最適劑量爲13~15mg/kg*d,一日兩次。但由於近年來發現其代謝產物具有肝臟...
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什麼是口服溶石療法?
...。目前臨牀最常用的口服溶石藥物有兩種:鵝去氧膽酸(CDCA)和熊去氧膽酸(UDCA)。其作用原理均在於,通過降低膽固醇的分泌使膽汁去飽和,然後利用不飽和膽汁的膽固醇溶解作用,使膽石表面的膽固醇分子不斷地被溶解,膽石體...
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ExtracellularSignal-RegulatedKinase–DependentStabilizationofHepaticLow-DensityLipoproteinReceptormRNAbyHerbalMedicineBerberine
...nds,namelyphorbol12-myristate13-acetate(PMA),abileacidchenodeoxycholicacid(CDCA),andaderivativeoffibricacidgemfibrozilhavebeenreportedtoregulateLDLRexpressionbymechanismsinvolvingpost-transcriptionalevents.InPMA-treatedHepG2cells,themRNAlevelofLDLRwasrapidlyelevated.IncreasedstabilityofthemRNApartia...
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武漢植物園在狗牙根耐鎘性鑑定及其與SSR標記的關聯分析研究中取得進展
...聯,其中與兩個或兩個以上性狀相關聯的位點31個,位點CDCA379–380-1和CDCA147-148-13同時與四個性狀關聯。校正後P<3.5×10-4水平下,檢測到37個關聯SSR位點,表型解釋度最高達到了41%。以上研究獲得了國家自然科學基金(No.31272194和No...
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ActivationofNuclearFactor(Erythroid-2Like)Factor2byToxicBileAcidsProvokesAdaptiveDefenseResponsestoEnhanceCellSurvivalattheEmergenceof
...rophobicsecondarybileacidproducedbycolonicmicrofloraonchenodeoxycholicacid(CDCA),isthemosttoxicbileacid,withgenotoxicandmutagenesis-enhancingproperties(Kawaleketal.,1983;Kozonietal.,2000).Inrodents,itinducesintrahepaticcholestasis-likehepatotoxicity(Staudingeretal.,2001),anditpromoteschemical-induce...
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什麼是肝膽管結石的灌注溶石治療?
...方膽汁酸製劑。以1%依地酸鈉(EDTA—2Na)與1%~2%膽酸鈉(或CDCA)配製成pH7.5~8.0的複方製劑。臨牀應用時每日1次經T管滴注,每次250ml,結石消失率約40%,有效率80%。副作用爲腹瀉、腹痛,療程長亦是其缺點。 (3)複方桔油乳劑。以...
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哪些膽囊結石病人禁用口服溶石藥物?
...發症,如胰腺炎、阻塞性黃疸及膽管炎等。 (2)孕婦,CDCA和UDCA均可通過胎盤屏障進入胎兒體內,目前尚未排除這兩種藥物對胎兒致畸的可能性。 (3)膽汁酸代謝紊亂,如嚴重肝病、阻塞性黃疸時。 (4)胃腸道潰瘍或炎症...
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DownregulationofEndothelin-1byFarnesoidXReceptorinVascularEndothelialCells
...stine.19FXRisactivatedbybileacids(BAs),suchasprimaryBAchenodeoxycholicacid(CDCA).20InadditiontoBAs,syntheticFXRagonistshavealsobeenidentified.21ActivationofFXRcausesbothfeedbackinhibitionofcholesterol7-hydroxylase(CYP7A1),therate-limitingenzymeinBAbiosynthesisfromcholesterol,andactivationofintestina...
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哪些因素可以影響口服溶石的療效?
...汁的過飽和狀態。 (6)服藥方法。有研究顯示每日口服CDCA375mg,則兩年結石全溶率爲5%,而劑量增至750mg時兩年結石全溶率則達27%。但應注意劑量大則副作用發生率高。此外,有人基於清晨膽汁膽固醇飽和度高的特點,將一日...
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膽囊結石有哪些非手術治療方法?
...在臨牀上使用的口服溶石藥物主要有兩種:鵝去氧膽酸(CDCA)和熊去氧膽酸(VDCA)。這兩種藥物通過降低膽汁膽固醇的分泌使膽汁去飽和,不飽和膽汁則具有溶解膽固醇的作用,使膽石表面的膽固醇分子不斷地被溶解,膽石體積逐漸...
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PNAS:斑馬魚研究T細胞發育
...的大量基因均發生失調。功能性和超顯性研究表明mcm2和cdca7處於Foxn1下游,且在胸腺上皮細胞中mcm2是Foxn1的直接靶基因。最後,研究人員證實foxn1和mcm2變體(morphant)中的胸腺缺陷有可能是因爲細胞增殖減少而非凋亡所致。這些...
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熊膽膠囊在熱症眼病中的應用研究
...歸膽、肝、心經,主要含熊去氧膽酸(UDCA)及鵝去氧膽酸(CDCA)2]。熊膽系傳統中醫中藥寶庫中的名貴藥材,在《神農本草經》、《唐本草》及《本草綱目》中均有記載。經臨牀應用證實有清熱解毒、明目、解痙作用、抗炎止痛功效。...
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TheMethylTransferasePRMT1FunctionsasCo-ActivatorofFarnesoidXReceptor(FXR)/9-cisRetinoidXReceptorandRegulatesTranscriptionofFXRResponsiveG
...rbileacids(BAs).FXRisboundtoandactivatedbybileacid,andchenodeoxycholicacid(CDCA)isthenaturalmostactiveligand.Uponactivation,FXRheterodimerizeswiththe9-cisretinoicXreceptor(RXR)andregulatesgenesinvolvedincholesterolandBAhomeostasis.6-EthylCDCA(6-ECDCA)isasyntheticBAthatbindsFXRandinducesgenetranscrip...
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老年性黃疸82例鑑別診斷分析
...性,對此種情況有人認爲血清膽酸及膽酸/鵝去氧膽酸(CA/CDCA)比值測定、血清脂蛋白X定量分析及動態觀察及B超、CT、MRI等影像學有助於二者鑑別。 3.6B超是黃疸鑑別的特異性、準確性較高的檢查與CT、MRI等相比,B超無創傷性,...
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TheHumanOrganicAnionTransporter2GeneIsTransactivatedbyHepatocyteNuclearFactor-4andSuppressedbyBileAcids
...mediatedrepressionofgenetranscription,westudiedwhetherchenodeoxycholicacid(CDCA)suppresseshOAT2geneexpressionbyinhibitingHNF-4-mediatedtransactivation.TreatmentofHuh7cellswithCDCAorthesyntheticfarnesoidXreceptor(FXR)agonistGW4064decreasedmRNAandproteinlevelsandalsonuclearbindingactivityofHNF-4.TheFX...
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PhysiologicalDifferencesbetweenHumanandRatPrimaryHepatocytesinResponsetoLiverXReceptorActivationby3-[3-[N-(2-Chloro-3-trifluoromethylbenzyl)-(
...pressionofCYP7A1mRNAanalyzedbyqPCR.B,cholicacid(CA)andchenodeoxycholicacid(CDCA)levelsincellculturemedia.Datarepresenttheaverageofduplicatecellculturedisheswithcellsfromeachofthree(A)ortwo(B)donors.LXRSuppressesKeyGlycolyticGenes.Anticipateddose-dependentinsulinregulationofkeygenesintheglycolyticand...
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Lymphocytegeneexpressioninsubjectsfedalow-cholinedietdiffersbetweenthosewhodeveloporgandysfunctionandthosewhodonot
...d4ofthemostunderexpressedgenes.Primersforthese8genesFOXA1,PRAME,TERT,CDCA8,CHEK1,IL2RB,TNFAIP3,andNFKBIAwerepurchasedfromSuperArray(Frederick,MD)aswas18SrRNA,whichwasusedasthenormalizationgene.EqualamountsofRNAwerepooledfromallsubjectsatbaselineanddepletion,respectively.Forallgenesbutone...
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FXRDeficiencyCausesReducedAtherosclerosisinLdlr-/-Mice
...setissue.8FXRisactivatedbyspecificbileacidsthatincludechenodeoxycholicacid(CDCA)andcholicacid,9-11andalsostructurallyunrelatedsyntheticcompounds,suchasGW406412andfexaramine.13FXRplaysanimportantroleinmaintainingbileacid,cholesterol,triglyceride,andglucosehomeostasis.12,14-18Importantly,plasmacholest...
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FarnesoidXReceptorLigandsInhibitVascularSmoothMuscleCellInflammationandMigration
...isnowrecognizedasabileacidreceptorwithligandsincludingchenodeoxycholicacid(CDCA)anddeoxycholicacid(DCA).11SyntheticFXRligandshavealsobeenidentified,suchasGW4064and6-ethyl-chenodeoxycholicacid(6ECDCA).12,13FXRactivationleadstoinductionofanorphannuclearreceptor,smallheterodimerpartner(SHP),thatmediate...
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APregnaneXReceptorAgonistwithUniqueSpecies-DependentStereoselectivityandItsImplicationsinDrugDevelopment
...sfectionassay(datanotshown).Likewise,FXRwasactivatedbychenodeoxycholicacid(CDCA),asexpected,butnotbyracemicS20,whentheFXR-responsivetk-EcRE-Lucreporterwascotransfected(Fig.3F).S20InducestheExpressionofDrug-MetabolizingEnzymesandTransportersinReporterGeneAssays,inHumanHepatocytes,andin“Humanized“...
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Impairednegativefeedbacksuppressionofbileacidsynthesisinmicelacking?Klotho
...shownatthetop.Miceweresacrificedattheendofeachregimen.EffectsofdietaryCAandCDCAontheexpressionofCyp7a1,Cyp8b1,andShpwereexamined.TotalRNA(30μg)fromtheliverwassubjectedtoNorthernblotanalysis.Themeanvaluesobtainedfrom6independentanimalsforeachgroupareshown.ErrorbarsindicateSD.*P0.05.Sincebileacidmeta...
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ConjugatedBileAcidsRegulateHepatocyteGlycogenSynthaseActivityInVitroandInVivoviaGiSignaling
...tussistoxin(PTX,300ng/ml)16hbeforebileacidexposure.CellswerethentreatedwithCDCA,taurochenodeoxycholicacid,andglycochenodeoxycholicacid(100µMeach).Cellswereisolated20minaftertreatmentandpreparedforSDS-PAGE,andimmunoblottingwasperformedtodeterminethephosphorylationofAKT(Ser473).Dataarefromarepre...
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TheFarnesoidXReceptorPromotesAdipocyteDifferentiationandRegulatesAdiposeCellFunctioninVivo
...iposetissueandthatthesyntheticFXRligandINT-747[6-ethylchenodeoxycholicacid(CDCA)]promotesadipocytesdifferentiationandlipidstorage.Inaddition,wedemonstratedthatinvivoadministrationofINT-747providesarobustinductionofFXRtargetgenesintheadiposetissueofwild-typemicebutnotinFXR-/-mice.Together,thesedataid...
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TheFarnesoidXReceptor
...isandInbornErrorsinPrimaryBileAcidSynthesisOriginally,chenodeoxycholicacid(CDCA),themostpotentnaturalagonistofhumanFXR(Figure1),wasevaluatedtotreateithergallstonediseaseorhypertriglyceridemia(Table2).However,sideeffectslikelivertoxicityanddiarrhealedtothewithdrawalofthecompoundfromclinicalapplicatio...
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第八章 膽胰疾病--第一節 膽囊炎、膽石症
...飲食調節,多能控制發作。文獻報導:採用去氧鵝膽酸(CDCA)、熊脫氧膽酸(UDCA)行溶石治療,可使部分膽囊結石縮小或消失,但用藥時間長(一般需半年~1.5年),大量應用能損害肝臟,停藥後結石又可復發,故對合適病...