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AHR與免疫系統之間的機制聯繫
芳香烴受體(AHR)是一個轉錄因子,其最爲人們所知的是它能調控二噁英等芳香烴的毒性:它的激活導致脫毒酶的生成。AHR在毒理及癌症研究方面已經得到深入研究,但過去人們並不知道它與免疫系統的機制聯繫。現在,兩個小...
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二噁英受容體可促進性激素分解
...名教授領導的研究小組發現,生物體內的二噁英受容體(AhR)能夠促進性激素受容體的分解。AhR與其他蛋白質結合,起到分解男女性激素酶的作用。這種蛋白質與其他蛋白質結合後,形成蛋白質複合體,從而獲得全新的機能。這...
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腎移植後急性體液性排斥反應逆轉
...至2003年6月間行同種異體屍腎移植490例,其中9例受者發生AHR,其診斷均依據Banff97標準,Banff分級爲Ⅱ級5例,Ⅲ級4例。患者發生AHR後均採用免疫吸附聯合FK506+MMF+激素治療,同時輔以連續性血液淨化。治療前、後行移植腎活檢...
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一氧化氮和內皮素-1與脂多糖誘發的持續性氣道高反應性的關係
...多次腹腔注射脂多糖(LPS)誘發的豚鼠持續性氣道高反應性(AHR)的關係。研究者將48只雄性Dunkin-Hartley豚鼠,隨機分爲LPS組和生理鹽水(NS)對照組。兩組分別每隔24h腹腔注射LPS(1mg/kg)或NS(1mL/kg)1次,連續4次。另取6只豚鼠不予任何處理作...
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免疫吸附聯合他克莫司和黴酚酸酯逆轉腎移植後急性體液性排斥反應
...至2003年6月間行同種異體屍腎移植490例,其中9例受者發生AHR,其診斷均依據Banff97標準,Banff分級爲Ⅱ級5例,Ⅲ級4例。患者發生AHR後均採用免疫吸附聯合FK506+MMF+激素治療,同時輔以連續性血液淨化。治療前、後行移植腎活檢...
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RoleofEndogenousXAP2ProteinontheLocalizationandNucleocytoplasmicShuttlingoftheEndogenousMouseAhb-1ReceptorinthePresenceandAbsenceofLiga
...atitisBvirusX-associatedprotein(XAP2)inthecontrolofarylhydrocarbonreceptor(AHR)stabilityandsubcellularlocation.StudieswereperformedinHepa-1cellstoevaluatethesefunctionsofXAP2onthemouseAhb-1receptorunderendogenousstoichiometry.TheAhb-1receptoriscytoplasmic,anditbecomespredominantlynuclearafter30to60m...
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原發性應激後缺乏CD4+T細胞的氣道高反應
...因敲除及轉基因小鼠的研究表明CD4+T細胞在氣道高反應(AHR)及氣道嗜酸性細胞浸潤的發生上起了重要的作用。但是由於其他的T細胞亞羣(CD8,NKT)在這些動物模型中可能也起了一定的作用,所以近期,國外學者做了一項研究,...
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TheArylHydrocarbonReceptorsansXenobiotics:EndogenousFunctioninGeneticModelSystems
【關鍵詞】SystemsFormorethan30years,thearylhydrocarbonreceptor[Ahreceptor(AHR)]hasbeenextensivelyscrutinizedasthecellularreceptorfornumerousenvironmentalcontaminants,includingpolychlorinateddioxins,dibenzofurans,andbiphenyls.Recentevidencearguesthatthisdescriptionisincompleteandperhapsmyopic.Ah...
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RepressionofArylHydrocarbonReceptor(AHR)SignalingbyAHRRepressor:RoleofDNABindingandCompetitionforAHRNuclearTranslocator
【關鍵詞】RepressionActivationofthearylhydrocarbonreceptor(AHR)by2,3,7,8-tetrachlorodibenzo-p-dioxincausesalteredgeneexpressionandtoxicity.TheAHRrepressor(AHRR)inhibitsAHRsignalingthroughaproposedmechanisminvolvingcompetitionwithAHRfordimerizationwithAHRnucleartranslocator(ARNT)andbindingtoAHR-...
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Associationstudyofdetoxificationgenesinagerelatedmaculardegeneration
...tidepolymorphisms(SNPs)weretypedforCYP1A1,CYP1A2,CYP2E1,CYP2D6,EPHX1,MnSOD,AhR,NAT2,CAT,GPX1,PON1,andADPRT1bymultiplexsnapshotsinglebaseprimerextensionmethod.Genesshowinghighlinkagedisequilibrium(LD)betweenSNPswereanalysedbyhaplotypeanalysis.GenesshowinglowLDwereassessedusingindividualSNPsbasedongen...
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TheArylHydrocarbonReceptorSignalingPathwayIsModifiedthroughInteractionswithaKelchProtein
【關鍵詞】ArylHydrocarbonReceptorThearylhydrocarbonreceptor(AHR)isaligand-activatedtranscriptionfactorwithimportantrolesinmetabolicadaptation,dioxintoxicology,andvasculardevelopment.Tounderstandthedetailsofthissignaltransductionpathway,wehaveusedtheyeasttwo-hybridsystemtoidentifyproteinsthatphy...
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MultipleMechanismsAreInvolvedinAhReceptor-MediatedCellCycleArrest
...lossordamagebyregenerationtorestoreliverbiomass.Thearylhydrocarbonreceptor(AhR)agonist2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)candisrupttheregenerativeprocess,asevidencedbysuppressionofDNAsynthesisinratprimaryhepatocytesincultureandinvivoliverregenerationafterpartialhepatectomy.Independentobservati...
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ResponsetoCommentson“CalpainMediatestheDioxin-InducedActivationandDown-RegulationoftheArylHydrocarbonReceptor“
...d,ourstudyhasbuiltonsomesignificantreportspublishedbyleadingscientistsintheAhRfield,asoutlinedinourmanuscript.Calpain-catalyzedproteolysisistypicallylimited,resultinginaclippedbutsubstantiallyintactprotein,andSuzukietal.(1988)haveproposedthatlimitedproteolysisbycalpaincouldrendersubstrateproteinsdes...
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非典型哮喘
...型哮喘患者行支氣管組胺激發試驗,測定氣道高反應性(AHR),結果試驗陽性313例(重度AHR35例,中度AHR83例,輕度AHR101例,極輕度AHR94例),陽性率59%。文中認爲支氣管組胺激發試驗是診斷非典型哮喘關鍵有效的方法。戚好文等[4]對...
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非典型哮喘
...型哮喘患者行支氣管組胺激發試驗,測定氣道高反應性(AHR),結果試驗陽性313例(重度AHR35例,中度AHR83例,輕度AHR101例,極輕度AHR94例),陽性率59%。文中認爲支氣管組胺激發試驗是診斷非典型哮喘關鍵有效的方法。戚好文等[4]對...
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FunctionalCharacterizationofthePromoterofHumanCarbonylReductase1(CBR1).RoleofXREElementsinMediatingtheInductionofCBR1byLigandsoftheAr
...elsweresignificantlyinduced(5-fold)bytheligandofthearylhydrocarbonreceptor(AHR)-naphthoflavone.DNAsequenceanalysisrevealedtwoxenobioticresponseelements(–122XREand–5783XRE)withpotentialregulatoryfunctions.CBR1promoterconstructslackingthe–122XREshoweddiminished(9-fold)promoteractivit...
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TCDD的致癌路徑被揭示
...發育的化合物,會黏附住細胞裏的arylhydrocarbonreceptor(簡稱AhR)這個受體蛋白,而細胞裏活化的AhR分子,會調控許多的基因,像是脂肪酸的代謝,細胞週期的調節活動,以及一些特定的免疫反應,這次研究人員卻發現TCDD分子的作用...
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DifferentialRegulationbyGlucocorticoidofInterleukin-13–inducedEosinophilia,Hyperresponsiveness,andGobletCellHyperplasiainMouseAirways
...sofbronchialasthmasuchaseosinophilicinfiltration,airwayhyperresponsiveness(AHR),andmucushypersecretion.Althoughglucocorticoidssuppressairwayinflammationandremainthemosteffectivetherapyforasthma,theeffectsofglucocorticoidsontheIL-13–dependentfeaturesareunknown.Westudiedtheeffectsofdexamethasoneoneo...
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遺傳發育所在神經特異性連接機制研究中取得新進展
...遺傳學篩選發現PAS-bHLH轉錄因子家族的兩個成員,AHA-1和AHR-1,對於BDU-PLM連接的形成至關重要。系統的細胞自主性拯救實驗結果證明:AHA-1和AHR-1,同時在BDU和PLM神經元中發揮功能,從而促進神經元的連接。AHA-1可結合cam-1的啓動子...
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支氣管哮喘患者IL-4測定的臨牀意義
...酶聯免疫法支氣管哮喘(簡稱哮喘)是以氣道高反應性(AHR)和慢性氣道炎症爲特徵的變態反應性疾病,有嗜酸性粒細胞(EOS)、肥大細胞(MC)、T淋巴細胞等多種炎症細胞和細胞因子參與。研究發現,哮喘的病理生理學特點是...
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兒童喘鳴和特應性其成年後發生哮喘風險增加
...和麪談。研究組測量了受試者對組織胺的氣道高反應性(AHR)、肺功能和對10種氣源性過敏原的皮膚針刺試驗的反應性。基線時,哮喘的時點患病率是4.1%。在第二次調查時增加至11.6%。在隨訪時,19.6%的受試者曾經歷過哮喘症狀。隨...
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污染驅動物種進化:小魚基因變異抵抗毒化物
...類,研究人員發現其主要的變化發生在芳香烴受體基因(AHR2)上,這種基因能夠製造釋放體內受污染毒素的蛋白質來保護自體不受損害。通常來講天然的AHR2很容易與污染物聯結,轉變爲對宿主動物有害的有毒基因。而在發生變異...
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崔紅生:支氣管哮喘診治思路與方法
...是一種慢性氣道炎症性疾病,氣道炎症與氣道高反應性(AHR)、氣流受限和呼吸道症狀密切相關,其中AHR和急性氣流受限是肺功能受損的主要表現形式。哮喘急性發作期,氣流受限主要表現爲急性支氣管痙攣,因此,及時控制症...
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Mitochondrialaldehydedehydrogenase-2(ALDH2)Glu504Lyspolymorphismcontributestothevariationinefficacyofsublingualnitroglycerin
...tudy,weshowthatthecommonG-to-Apolymorphisminexon12ofALDH2—resultinginaGlu504LysreplacementthatvirtuallyeliminatesALDH2activityinbothheterozygotesandhomozygotes—isassociatedwithalackofefficacyofsublingualGTNinChinesesubjects.Wealsoshowthatthecatalyticefficiency(Vmax/Km)ofGTNmetabolismoftheGlu504p...
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α-甲酰基輔酶A消旋酶檢測的臨牀意義
...雜誌2007Vol.28No.1P.46-49醫學空間(MEDcyber.com)7月3日消息,P504S可作爲前列腺癌的腫瘤標記物,在前列腺穿刺活檢組織病理診斷中有一定輔助診斷價值。前列腺癌症狀的出現及其嚴重程度,取決於癌腫生長的速度和壓迫尿道的程度...
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T-BetPolymorphismsAreAssociatedwithAsthmaandAirwayHyperresponsiveness
...andIFN-production.KnockoutmicelackingT-betdevelopairwayhyperresponsiveness(AHR)tomethacholine,peribronchialeosinophilicandlymphocyticinflammation,andincreasedtypeIIIcollagendepositionbelowthebronchialepitheliumbasementmembrane,reminiscentofbothacuteandchronicasthmahistopathology.Littleisknownregardi...
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α-甲酰輔酶A消旋酶免疫組化染色--診斷前列腺癌的新方法
...6No.6P.375-37814(上海)爲了探討α-甲酰輔酶A消旋酶(AMACR,P504s)免疫組化染色在前列腺癌診斷中的價值。研究者前列腺癌(PCa)標本46例(A期1例,B期19例,C期14例,D期12例,Ⅰ級4例,Ⅱ級14例,Ⅲ級28例),良性前列腺增生(BPH)53例,前列...
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交通事故致嚴重多發傷504例急救分析
...傷員的存亡。現將我院急診科1998年12月~2003年12月就治的504例交通事故致嚴重多發傷病人報告如下。 1資料與方法 1.1一般資料本組504例中,男356例,女148例,年齡5~70歲,平均30.8歲,18~55歲430例,佔85.31%。嚴重顱腦外傷...
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ADioxin-ResponsiveEnhancer3‘oftheHumanCYP1A2Gene
...CYP1AgenesandCYP1B1aretranscriptionallyinducedbythearylhydrocarbonreceptor(AhR),aligand-activatedtranscriptionfactorthatbinds2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD,dioxin).AlthoughtheTCDD-responsiveenhancersforCYP1A1andCYP1B1arewellcharacterized,asimilarCYP1A2enhancerhasnotbeenidentified.Inthehuma...
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ARolefortheArylHydrocarbonReceptorinRegulationofIschemia-InducedAngiogenesis
【摘要】Objective—Thearylhydrocarbonreceptor(AHR)isatranscriptionfactorthatbindstoDNAasaheterodimerwiththeAHRnucleartranslocator(ARNT)afterinteractionwithligandssuchaspolycyclicandhalogenatedaromatichydrocarbonsfoundintobaccosmokeandtheenvironment.WehaveinvestigatedtheinteractionbetweenAHR...