Selectivetyrosinekinaseinhibitionbyimatinibmesylateforthetreatmentofautoimmunearthritis
...esylate(imatinib)isatyrosinekinaseinhibitordevelopedtotreatBcr/Abl-expressingleukemiasandsubsequentlyfoundtotreatc-Kit–expressinggastrointestinalstromaltumors.Wedemonstratethatimatinibpotentlypreventsandtreatsmurinecollagen-inducedarthritis(CIA).Wefurthershowthatmicromolarconcentrationsofimatiniba...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第10期NovelRolesofLocalInsulin-LikeGrowthFactor-ActivationinGastricUlcerHealing
【摘要】Thepreciseroleofinsulin-likegrowthfactor(IGF)-1ingastriculcerhealingisunknown.Inexperimentalratgastriculcers,weexaminedexpressionofIGF-1mRNAandproteinbyreversetranscriptase-polymerasechainreactionorenzyme-linkedimmunosorbentassayandimmunostaining,respectively.Inculturedratgastricepitheli...
醫源資料庫;在線期刊;美國病理學雜誌;2007年第169卷第4期高效液相色譜法監測環孢素A的全血濃度
...長214nm,流速1ml/min,柱溫爲60℃。結果:環孢素A濃度在50ng/ml~2000ng/ml範圍內線性良好(r=0.9998),平均方法回收率爲99.7%,日內及日間精密度<6%(n=5)。結論:本方法簡便、準確、可靠,能較好的滿足臨牀血藥濃度監測的需要。【關...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文PhosducinandPhosducin-likeProteinAttenuateG-Protein-CoupledReceptor-MediatedInhibitionofVoltage-GatedCalciumChannelsinRatSympatheticNeurons
...(PDCL)isthesequestrationof“free“Gfromtheplasmamembrane,therebyterminatingsignalingbyG.ThefunctionalimpactofheterologouslyexpressedPDCandPDCLonN-typecalciumchannel(CaV2.2)modulationwasexaminedinsympatheticneurons,isolatedfromratsuperiorcervicalganglia,usingwhole-cellvoltageclamp.ExpressionofPDCan...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第7期反相高效液相色譜法分析注射用鹽酸洛美沙星
...20μL時,線性濃度範圍爲5~215μg/mL;最低檢測限(LOD)爲12ng/mL(S/N=3),最低定量限(LOQ)爲60ng/mL(S/N=10);日內精密度(RSD)爲0.85%(n=5),日間精密度(RSD)爲1.35%(n=5)。該方法簡便、快速,專屬性強,可用於對注射用鹽酸洛美沙星的含量測定。...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文毛細管氣相色譜法測定吡喹酮中5種有機溶劑殘留量
...口溫度:200℃;氫火焰檢測器溫度:260℃;檢測器量程:Range=5;進樣量:1.0μL。乙醇與丙酮的分離度爲2.95。2.2 線性範圍及標準曲線 用N,N-二甲基乙酰胺分別製備含乙醇、丙酮、二氯甲烷、乙酸乙酯、苯均爲5、10、15、20、30μg/mL的...
藥品天地;專業藥學;實驗技術;色譜技術;色譜論文MutationswithinSox2/SOX2areassociatedwithabnormalitiesinthehypothalamo-pituitary-gonadalaxisinmiceandhumans
...GeneticsUnit,InstituteofChildHealth,UniversityCollegeLondon,London,UnitedKingdom.3DivisionofDevelopmentalGenetics,MedicalResearchCouncilNationalInstituteforMedicalResearch,London,UnitedKingdom.4CancerResearchUK,SkinTumourLab,UniversityofLondon,London,UnitedKingdom.5CenterofPaediatricEndocrinology,De...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第9期RevascularizationofischemictissuesbyPDGF-CCviaeffectsonendothelialcellsandtheirprogenitors
...Moléculaire(IRIBHM),FreeUniversityofBrussels,Brussels,Belgium.AbstractTheangiogenicmechanismandtherapeuticpotentialofPDGF-CC,arecentlydiscoveredmemberoftheVEGF/PDGFsuperfamily,remainincompletelycharacterized.HerewereportthatPDGF-CCmobilizedendothelialprogenitorcellsinischemicconditions;induceddiffe...
醫源資料庫;在線期刊;臨牀研究雜誌;2005年第115卷第1期HMG-CoAreductaseinhibitorsimvastatinmitigatesVEGF-inducedinside-outsignalingtoextracellularmatrixbypreventingRhoAactivation
...meA(HMG-CoA)reductaseinhibitorsexertmodulatoryeffectsonanumberofcellsignalingcascadesbypreventingthesynthesisofvariousisoprenoidsderivedfromthemevalonatepathway.Inthepresentstudy,wedescribeanovelpleiotropiceffectofHMG-CoAreductaseinhibitors,alsocommonlyknownasstatins,onvascularendothelialgrowthfacto...
醫源資料庫;在線期刊;美國生理學雜誌;2006年第289卷第11期雙歧桿菌表面分子對LPS在小鼠體內調節胸腺細胞凋亡的觀察
...rfacemoleculesonapoptosisofmurinethymocytesinducedbyLPSinvivo YUZhendong,HUHong.ClinicalLaboratoryofUnionHospital,TongjiMedicalUniversity,Wuhan430022 【Abstract】 Objective ToinvestigatetheregulationofBifidobacteriumbifidumsurfacemolecules-wholepeptidoglycan(WPG),lipoteichoicacid(LTA...
合作平臺;醫學論文;臨牀醫學與專科論文;檢驗醫學