生大黃對急性胰腺炎治療價值的臨牀研究
...AP發病機制極其複雜,新近研究表明,SIRS(全身嚴重反應綜合徵)的發生,其中細胞因子的過度生成是一種重要的因素。TNF主要分爲活化的單細胞產生的TNF—a和活化T細胞產生的TNF-β。過量的TNF—a可導致組織的炎性損害,加重毛細...
合作平臺;醫學論文;中西醫結合論文;藥物與臨牀Asthmaticbronchialepithelialcellshaveadeficientinnateimmuneresponsetoinfectionwithrhinovirus
1TheBrookeLaboratories,UniversityofSouthampton,SouthamptonSO166YD,UK2DepartmentofRespiratoryMedicine,NationalHeartandLungInstitute,ImperialCollegeLondon,LondonW2IPG,England,UK3DepartmentofExperimentalMedicine,HumanAnatomyDivision,UniversityofPalermo,Palermo90127,ItalyRhinovirusesarethemajortriggerof...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第201卷第6期DisruptionofNrf2enhancessusceptibilitytosevereairwayinflammationandasthmainmice
...nes.WeshowthatdisruptionoftheNrf2geneleadstosevereallergen-drivenairwayinflammationandhyperresponsivenessinmice.EnhancedasthmaticresponseasaresultofovalbuminsensitizationandchallengeinNrf2-disruptedmicewasassociatedwithmorepronouncedmucuscellhyperplasiaandinfiltrationofeosinophilsintothelungsthansee...
醫源資料庫;在線期刊;實驗醫學雜誌;2005年第202卷第1期Adenosinemetabolismandmurinestrain–specificIL-4–inducedinflammation,emphysema,andfibrosis
...ofTgIL-4inBalb/candC57BL/6mice.Intheformer,IL-4causedmodesteosinophilicinflammationandmildairwayfibrosisanddidnotshortensurvival.InC57BL/6mice,IL-4causedprofoundeosinophilicinflammation,airwayfibrosis,emphysematousalveolardestruction,andprematuredeath.Thesedifferencescouldnotbeaccountedforbychangesi...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第5期體外循環對中性粒細胞膜結合彈性蛋白酶的影響
...)能通過激活循環中細胞與體液成分,引起全身炎性反應綜合徵[1,2]。激活的中性粒細胞釋放出的彈性蛋白酶,被認爲是能夠降解各種蛋白如彈性蛋白、纖維蛋白、糖蛋白等強有力的蛋白水解酶之一[3]。心內直視手術的病...
醫源資料庫;在線期刊;中華現代臨牀醫學雜誌;2006年第4卷第1期IntraabdominalZygomycosisCausedbySyncephalastrumracemosumInfectionSuccessfullyTreatedwithPartialSurgicalDebridementandHigh-DoseAmphotericinBL
...strumracemosum,whichwassuccessfullytreatedwithpartialsurgicaldebridementandamphotericinBlipidcomplex.CASEREPORTA23-year-oldpreviouslywellmalepresentedwithalargeabdominalwoundafterfallingandbeingimpaledonasteelreinforcingrod.Hisabdominalwallwasperforated;hehadspleniclacerations,mesenterictears,colona...
醫源資料庫;在線期刊;微生物臨牀雜誌;2005年第43卷第11期CriticalroleofendothelialCXCR2inLPS-inducedneutrophilmigrationintothelung
...otacticforPMNs,CXCR2isthoughttorecruitPMNsbyinducingchemotacticmigration.InamodelofPMNrecruitmenttothelung,aerosolizedbacterialLPSinhalationinducedPMNrecruitmenttothelunginwild-typemice,butnotinlittermateCXCR2–/–mice.Surprisingly,lethallyirradiatedwild-typemicereconstitutedwithCXCR2–/–BMstil...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第3期ABoronic-ChalconeDerivativeExhibitsPotentAnticancerActivitythroughInhibitionoftheProteasome
...edaseriesofboronicchalconesfortheiranticanceractivityandmechanismsofaction.Amongtheeightchalconederivativestested,3,5-bis-(4-boronicacid-benzylidene)-1-methyl-piperidin-4-one(AM114)exhibitedmostpotentgrowthinhibitoryactivitywithIC50valuesof1.5and0.6µMin3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl...
醫源資料庫;在線期刊;分子藥理學雜誌;2006年第68卷第7期Soydietworsensheartdiseaseinmice
...ioninatransgenicmousemodelofhypertrophiccardiomyopathy.Onasoydiet,maleswithamutationinthe-myosinheavychaingeneprogresstodilationandheartfailure.However,malesfedacaseindietnolongerdeterioratetosevere,dilatedcardiomyopathy.Remarkably,theirLVsizeandcontractilefunctionarepreserved.Further,thisdietpreven...
醫源資料庫;在線期刊;臨牀研究雜誌;2006年第116卷第1期住院病人體溫記錄的改進與應用
...統體溫單格式(7天)。爲每24h監測6次,監測時間分別爲4Am、8Am、12Am、4Pm、8Pm、12Pm。甲種體溫單用於新入院、低熱等每日監測4~6次體溫者。乙種體溫單改爲每24h監測1次,監測時間爲4Pm,月爲空白。每頁體溫單可記錄住院天數...
醫源資料庫;在線期刊;中國民康醫學;2008年第20卷第16期